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- W4205964209 abstract "We examined the regulation of dendritic spines and synapses by epileptiform activity (EA) in rat hippocampal slice cultures. EA, which was induced by a GABA(A) receptor inhibitor, gabazine, reduced pyramidal neuron spine density by approximately 50% after 48 h and also caused an increase in the average length of remaining spines. To directly determine the effects of EA on synapses, we used fluorescent protein-tagged PSD95, which marks postsynaptic densities. EA induced a net loss of synapses on spines but not shafts; conversely, activity blockade (TTX) induced a loss of shaft synapses. Time-lapse confocal imaging in live tissue slices revealed that EA (1) shifts the balance of synapse gain and loss in dendrites leading to a net loss of spine synapses and (2) induces the formation of new filopodia-like dendritic structures having abnormally slow motility. These results identify EA-induced changes in the density and distribution of synaptic structures on dendrites. PMID: 15953736 Funding information This work was supported by: NINDS NIH HHS, United States Grant ID: R29 NS037159 NIDCD NIH HHS, United States Grant ID: R01 DC002961 NINDS NIH HHS, United States Grant ID: NS37159 NIDCD NIH HHS, United States Grant ID: DC02961" @default.
- W4205964209 created "2022-01-26" @default.
- W4205964209 creator A5086447180 @default.
- W4205964209 date "2005-06-24" @default.
- W4205964209 modified "2023-09-27" @default.
- W4205964209 title "Faculty Opinions recommendation of Regulation of hippocampal synapse remodeling by epileptiform activity." @default.
- W4205964209 doi "https://doi.org/10.3410/f.1026477.325191" @default.
- W4205964209 hasPublicationYear "2005" @default.
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