Matches in SemOpenAlex for { <https://semopenalex.org/work/W4205967874> ?p ?o ?g. }
Showing items 1 to 72 of
72
with 100 items per page.
- W4205967874 abstract "Abstract Germline integrity is critical for progeny fitness. Organisms deploy the DNA damage response (DDR) signalling to protect germline from genotoxic stress, facilitating cell-cycle arrest of germ cells and DNA repair or their apoptosis. Cell-autonomous regulation of germline quality is well-studied; however, how quality is enforced cell non-autonomously on sensing somatic DNA damage is less known. Using Caenorhabditis elegans, we show that DDR disruption, only in the uterus, when insulin-IGF-1 signalling (IIS) is low, arrests germline development and induces sterility in a FOXO/DAF-16 transcription factor (TF)-dependent manner. Without FOXO/DAF-16, germ cells of the IIS mutant escape arrest to produce poor quality oocytes, showing that the TF imposes strict quality control during low IIS. In response to low IIS in neurons, FOXO/DAF-16 works cell autonomously as well as non-autonomously to facilitate the arrest. Activated FOXO/DAF-16 promotes transcription of checkpoint and DDR genes, protecting germline integrity. However, on reducing DDR during low IIS, the TF decreases ERK/MPK-1 signaling below a threshold, and transcriptionally downregulates genes involved in spermatogenesis-to-oogenesis switch as well as cdk-1/Cyclin B to promote germline arrest. Altogether, our study reveals how cell non-autonomous function of FOXO/DAF-16 promotes germline quality and progeny fitness in response to somatic DNA damage." @default.
- W4205967874 created "2022-01-26" @default.
- W4205967874 creator A5021656662 @default.
- W4205967874 creator A5022217457 @default.
- W4205967874 creator A5023442283 @default.
- W4205967874 creator A5023961958 @default.
- W4205967874 creator A5036383060 @default.
- W4205967874 creator A5037015852 @default.
- W4205967874 creator A5048478690 @default.
- W4205967874 creator A5058168727 @default.
- W4205967874 creator A5088458633 @default.
- W4205967874 date "2022-01-21" @default.
- W4205967874 modified "2023-09-27" @default.
- W4205967874 title "A cell non-autonomous FOXO/DAF-16-mediated germline quality assurance program that responds to somatic DNA damage" @default.
- W4205967874 doi "https://doi.org/10.21203/rs.3.rs-1119544/v1" @default.
- W4205967874 hasPublicationYear "2022" @default.
- W4205967874 type Work @default.
- W4205967874 citedByCount "0" @default.
- W4205967874 crossrefType "posted-content" @default.
- W4205967874 hasAuthorship W4205967874A5021656662 @default.
- W4205967874 hasAuthorship W4205967874A5022217457 @default.
- W4205967874 hasAuthorship W4205967874A5023442283 @default.
- W4205967874 hasAuthorship W4205967874A5023961958 @default.
- W4205967874 hasAuthorship W4205967874A5036383060 @default.
- W4205967874 hasAuthorship W4205967874A5037015852 @default.
- W4205967874 hasAuthorship W4205967874A5048478690 @default.
- W4205967874 hasAuthorship W4205967874A5058168727 @default.
- W4205967874 hasAuthorship W4205967874A5088458633 @default.
- W4205967874 hasBestOaLocation W42059678741 @default.
- W4205967874 hasConcept C104317684 @default.
- W4205967874 hasConcept C105696609 @default.
- W4205967874 hasConcept C109825262 @default.
- W4205967874 hasConcept C134305767 @default.
- W4205967874 hasConcept C143425029 @default.
- W4205967874 hasConcept C2778944004 @default.
- W4205967874 hasConcept C2779122487 @default.
- W4205967874 hasConcept C29537977 @default.
- W4205967874 hasConcept C54355233 @default.
- W4205967874 hasConcept C552990157 @default.
- W4205967874 hasConcept C86339819 @default.
- W4205967874 hasConcept C86803240 @default.
- W4205967874 hasConcept C95444343 @default.
- W4205967874 hasConceptScore W4205967874C104317684 @default.
- W4205967874 hasConceptScore W4205967874C105696609 @default.
- W4205967874 hasConceptScore W4205967874C109825262 @default.
- W4205967874 hasConceptScore W4205967874C134305767 @default.
- W4205967874 hasConceptScore W4205967874C143425029 @default.
- W4205967874 hasConceptScore W4205967874C2778944004 @default.
- W4205967874 hasConceptScore W4205967874C2779122487 @default.
- W4205967874 hasConceptScore W4205967874C29537977 @default.
- W4205967874 hasConceptScore W4205967874C54355233 @default.
- W4205967874 hasConceptScore W4205967874C552990157 @default.
- W4205967874 hasConceptScore W4205967874C86339819 @default.
- W4205967874 hasConceptScore W4205967874C86803240 @default.
- W4205967874 hasConceptScore W4205967874C95444343 @default.
- W4205967874 hasLocation W42059678741 @default.
- W4205967874 hasLocation W42059678742 @default.
- W4205967874 hasOpenAccess W4205967874 @default.
- W4205967874 hasPrimaryLocation W42059678741 @default.
- W4205967874 hasRelatedWork W1583112849 @default.
- W4205967874 hasRelatedWork W2000783020 @default.
- W4205967874 hasRelatedWork W2033497427 @default.
- W4205967874 hasRelatedWork W2035707307 @default.
- W4205967874 hasRelatedWork W2051303735 @default.
- W4205967874 hasRelatedWork W2095250167 @default.
- W4205967874 hasRelatedWork W2127244622 @default.
- W4205967874 hasRelatedWork W2162875712 @default.
- W4205967874 hasRelatedWork W4241031272 @default.
- W4205967874 hasRelatedWork W4302275737 @default.
- W4205967874 isParatext "false" @default.
- W4205967874 isRetracted "false" @default.
- W4205967874 workType "article" @default.