Matches in SemOpenAlex for { <https://semopenalex.org/work/W4205977586> ?p ?o ?g. }
- W4205977586 endingPage "101488" @default.
- W4205977586 startingPage "101488" @default.
- W4205977586 abstract "Combinatorial therapy is highly recommended for treating age-linked dysfunctions since multiple organs and biological targets are simultaneously affected. Ayurveda employs a holistic treatment strategy where drug combinations of higher therapeutic potential is utilized as a treatment regimen. Rasayanas are one of the most commonly used formulation in Ayurveda. Narasimha Rasayana is a predominant formulation in Ayurveda reported for bringing out anti-aging and rejuvenation effects. However, the mechanism of action of Narasimha Rasayana is least studied due to its complexity in terms of large number of bioactive ingredients present. The objective of current study is to elucidate the molecular mechanism of action of bioactive components present in Narasimha Rasayana. Systems pharmacology approach was employed for the elucidation of molecular mechanism of bioactive components present in Narasimha Rasayana. The target genes, interacting partners, diseases transcription factors and pathways associated with bioactive components were explored to understand the molecular mechanism. Systems pharmacology studies concluded the interactions of bioactive components with key molecular components of pathways reported for aging. We have identified the interaction of bioactive components present in Narasimha Rasayana with key biomarkers involved in aging pathways such as mTOR and insulin signalling pathways. The bioactive components such as gallic acid, epicathechin, plumbagin, gallic acid, ellagic acid, quercetin and genistein were found to interact with components of PI3K/AKT signalling pathway, insulin signalling pathway and mTOR signalling pathway via FOXO transcription factors." @default.
- W4205977586 created "2022-01-25" @default.
- W4205977586 creator A5053581026 @default.
- W4205977586 creator A5066171615 @default.
- W4205977586 creator A5081238938 @default.
- W4205977586 date "2022-03-01" @default.
- W4205977586 modified "2023-10-18" @default.
- W4205977586 title "Developing a molecular roadmap to Narasimha Rasayana: A system Polypharmacology approach" @default.
- W4205977586 cites W1513495951 @default.
- W4205977586 cites W1987003603 @default.
- W4205977586 cites W1993745784 @default.
- W4205977586 cites W2021460489 @default.
- W4205977586 cites W2034537627 @default.
- W4205977586 cites W2041649929 @default.
- W4205977586 cites W2047125854 @default.
- W4205977586 cites W2058864879 @default.
- W4205977586 cites W2063912958 @default.
- W4205977586 cites W2070403076 @default.
- W4205977586 cites W2096864392 @default.
- W4205977586 cites W2111825994 @default.
- W4205977586 cites W2116490460 @default.
- W4205977586 cites W2118618949 @default.
- W4205977586 cites W2124679671 @default.
- W4205977586 cites W2137676811 @default.
- W4205977586 cites W2139653188 @default.
- W4205977586 cites W2144082963 @default.
- W4205977586 cites W2149368702 @default.
- W4205977586 cites W2154038580 @default.
- W4205977586 cites W2159675211 @default.
- W4205977586 cites W2167795228 @default.
- W4205977586 cites W2342805349 @default.
- W4205977586 cites W2510638715 @default.
- W4205977586 cites W2513016732 @default.
- W4205977586 cites W2537623931 @default.
- W4205977586 cites W2537679995 @default.
- W4205977586 cites W2568166803 @default.
- W4205977586 cites W2582433095 @default.
- W4205977586 cites W2594490647 @default.
- W4205977586 cites W2596529026 @default.
- W4205977586 cites W2605910555 @default.
- W4205977586 cites W2617171469 @default.
- W4205977586 cites W2623638995 @default.
- W4205977586 cites W265492837 @default.
- W4205977586 cites W2763682406 @default.
- W4205977586 cites W2766490148 @default.
- W4205977586 cites W2794019774 @default.
- W4205977586 cites W2801088198 @default.
- W4205977586 cites W2806966362 @default.
- W4205977586 cites W2894643726 @default.
- W4205977586 cites W2898251365 @default.
- W4205977586 cites W2900810481 @default.
- W4205977586 cites W2912535974 @default.
- W4205977586 cites W2950373073 @default.
- W4205977586 cites W3018432144 @default.
- W4205977586 cites W3118967392 @default.
- W4205977586 cites W39701970 @default.
- W4205977586 cites W4294216483 @default.
- W4205977586 doi "https://doi.org/10.1016/j.genrep.2021.101488" @default.
- W4205977586 hasPublicationYear "2022" @default.
- W4205977586 type Work @default.
- W4205977586 citedByCount "0" @default.
- W4205977586 crossrefType "journal-article" @default.
- W4205977586 hasAuthorship W4205977586A5053581026 @default.
- W4205977586 hasAuthorship W4205977586A5066171615 @default.
- W4205977586 hasAuthorship W4205977586A5081238938 @default.
- W4205977586 hasConcept C104317684 @default.
- W4205977586 hasConcept C111472728 @default.
- W4205977586 hasConcept C138885662 @default.
- W4205977586 hasConcept C185592680 @default.
- W4205977586 hasConcept C202751555 @default.
- W4205977586 hasConcept C2776120743 @default.
- W4205977586 hasConcept C55493867 @default.
- W4205977586 hasConcept C62478195 @default.
- W4205977586 hasConcept C70721500 @default.
- W4205977586 hasConcept C86339819 @default.
- W4205977586 hasConcept C86554907 @default.
- W4205977586 hasConcept C86803240 @default.
- W4205977586 hasConcept C89611455 @default.
- W4205977586 hasConcept C98274493 @default.
- W4205977586 hasConceptScore W4205977586C104317684 @default.
- W4205977586 hasConceptScore W4205977586C111472728 @default.
- W4205977586 hasConceptScore W4205977586C138885662 @default.
- W4205977586 hasConceptScore W4205977586C185592680 @default.
- W4205977586 hasConceptScore W4205977586C202751555 @default.
- W4205977586 hasConceptScore W4205977586C2776120743 @default.
- W4205977586 hasConceptScore W4205977586C55493867 @default.
- W4205977586 hasConceptScore W4205977586C62478195 @default.
- W4205977586 hasConceptScore W4205977586C70721500 @default.
- W4205977586 hasConceptScore W4205977586C86339819 @default.
- W4205977586 hasConceptScore W4205977586C86554907 @default.
- W4205977586 hasConceptScore W4205977586C86803240 @default.
- W4205977586 hasConceptScore W4205977586C89611455 @default.
- W4205977586 hasConceptScore W4205977586C98274493 @default.
- W4205977586 hasLocation W42059775861 @default.
- W4205977586 hasOpenAccess W4205977586 @default.
- W4205977586 hasPrimaryLocation W42059775861 @default.
- W4205977586 hasRelatedWork W1964722019 @default.
- W4205977586 hasRelatedWork W1996335063 @default.