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• W4206021504 abstract "Abstract Photothermal therapy is becoming one subject of intense investigation for cancer treatment. However, due to the light absorption and light scattering of skin tissues, it is challenging to directly transport light energy into subcutaneous tissues with a depth over 1.0 cm. This research puts forward a technique termed as Injectable Optical System (IOS) for guiding near‐infrared light (NIR) into deep tissues by optical fibers, which is unattainable by regular NIR photothermal therapy, despite that NIR light is testified as the preferred light window with deepest tissue penetration. Meanwhile, the technique of IOS also possesses the abilities of drug delivery and synchronous sampling the diseased tissues during the treatment of photothermal therapy. According to in vitro and in vivo studies, IOS exhibits distinct advantages in transporting light energy into deeper subcutaneous tissues in contrast with traditional light irradiation on skins. Light would directly transport through the pathway to tumor tissues to realize hyperthermia effect without causing energy loss. Since IOS owns the benefits of clinical biopsy and radiofrequency ablation, it would be a powerful supplement to therapeutic methodologies for treating subcutaneous diseases. The easy modification of IOS offers great promise to combine other analytical techniques to achieve the in situ detection and deep‐sited tumors treatment." @default.
• W4206021504 created "2022-01-25" @default.
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• W4206021504 date "2021-12-30" @default.
• W4206021504 modified "2023-09-27" @default.
• W4206021504 title "Injectable Optical System for Drug Delivery, Ablation, and Sampling in Deep Tissue" @default.
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• W4206021504 doi "https://doi.org/10.1002/admt.202101464" @default.
• W4206021504 hasPublicationYear "2021" @default.
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