Matches in SemOpenAlex for { <https://semopenalex.org/work/W4206023390> ?p ?o ?g. }
- W4206023390 endingPage "104934" @default.
- W4206023390 startingPage "104934" @default.
- W4206023390 abstract "This study aimed to investigate the effects of capsaicin on invasion and metastasis of esophageal squamous cell carcinoma (ESCC) and the underlining mechanisms. Cldn3 expression was detected in cancerous and adjacent normal esophageal tissues. The association of Cldn3 with clinical data was analyzed. The migration and invasion of ESCC cells was investigated by exposing to capsaicin or with CLDN3 silencing or Cldn3 overexpression. The effects of capsaicin on lung metastasis were evaluated. Cldn3 expression in ESCC was associated with better prognosis. Capsaicin attenuated migration, invasion, and metastasis of ESCC and inhibited epithelial-mesenchymal transition (EMT) in a dose-dependent manner. Cldn3 overexpression, like exposing to capsaicin, inhibited migration, invasion and EMT, and vice versa. CLDN3 silencing attenuated inhibition of migration and invasion and EMT by exposing to capsaicin. In conclusion, Cldn3 showed a better prognosis in ESCC. Capsaicin might inhibit migration and invasion and metastasis of ESCC via overexpression of Cldn3 and inhibiting EMT." @default.
- W4206023390 created "2022-01-26" @default.
- W4206023390 creator A5040899817 @default.
- W4206023390 creator A5041940361 @default.
- W4206023390 creator A5058555669 @default.
- W4206023390 creator A5059096816 @default.
- W4206023390 creator A5062896028 @default.
- W4206023390 creator A5068194594 @default.
- W4206023390 creator A5068954460 @default.
- W4206023390 creator A5071550953 @default.
- W4206023390 creator A5081271358 @default.
- W4206023390 creator A5081673829 @default.
- W4206023390 date "2022-02-01" @default.
- W4206023390 modified "2023-10-16" @default.
- W4206023390 title "Capsaicin inhibits migration and invasion via inhibiting epithelial-mesenchymal transition in esophageal squamous cell carcinoma by up-regulation of claudin-3 expression" @default.
- W4206023390 cites W1230171729 @default.
- W4206023390 cites W1562304075 @default.
- W4206023390 cites W1820737158 @default.
- W4206023390 cites W1829590312 @default.
- W4206023390 cites W1964081206 @default.
- W4206023390 cites W1965402438 @default.
- W4206023390 cites W1971911970 @default.
- W4206023390 cites W1979988883 @default.
- W4206023390 cites W1984198459 @default.
- W4206023390 cites W1987653003 @default.
- W4206023390 cites W2011630646 @default.
- W4206023390 cites W2016715472 @default.
- W4206023390 cites W2018397538 @default.
- W4206023390 cites W2023167885 @default.
- W4206023390 cites W2025647419 @default.
- W4206023390 cites W2029409519 @default.
- W4206023390 cites W2030599751 @default.
- W4206023390 cites W2038204970 @default.
- W4206023390 cites W2039584595 @default.
- W4206023390 cites W2042198997 @default.
- W4206023390 cites W2045247602 @default.
- W4206023390 cites W2046997489 @default.
- W4206023390 cites W2055811191 @default.
- W4206023390 cites W2059375118 @default.
- W4206023390 cites W2065062437 @default.
- W4206023390 cites W2066840282 @default.
- W4206023390 cites W2074288885 @default.
- W4206023390 cites W2080477547 @default.
- W4206023390 cites W2083429514 @default.
- W4206023390 cites W2089569798 @default.
- W4206023390 cites W2091720415 @default.
- W4206023390 cites W2093208620 @default.
- W4206023390 cites W2107277218 @default.
- W4206023390 cites W2110623520 @default.
- W4206023390 cites W2120537788 @default.
- W4206023390 cites W2120914031 @default.
- W4206023390 cites W2121291985 @default.
- W4206023390 cites W2129269286 @default.
- W4206023390 cites W2131071353 @default.
- W4206023390 cites W2139796120 @default.
- W4206023390 cites W2141250106 @default.
- W4206023390 cites W2141862970 @default.
- W4206023390 cites W2145002455 @default.
- W4206023390 cites W2145665625 @default.
- W4206023390 cites W2152181954 @default.
- W4206023390 cites W2152544677 @default.
- W4206023390 cites W2158402820 @default.
- W4206023390 cites W2163028894 @default.
- W4206023390 cites W2169064387 @default.
- W4206023390 cites W2229392948 @default.
- W4206023390 cites W2268572259 @default.
- W4206023390 cites W2476704480 @default.
- W4206023390 cites W2584880497 @default.
- W4206023390 cites W2606259722 @default.
- W4206023390 cites W2726817744 @default.
- W4206023390 cites W2746554938 @default.
- W4206023390 cites W2749020974 @default.
- W4206023390 cites W2767227657 @default.
- W4206023390 cites W2774462428 @default.
- W4206023390 cites W2787614032 @default.
- W4206023390 cites W2791785349 @default.
- W4206023390 cites W2907499217 @default.
- W4206023390 cites W2911934864 @default.
- W4206023390 cites W2913231079 @default.
- W4206023390 cites W2980972694 @default.
- W4206023390 cites W2996845968 @default.
- W4206023390 cites W302351004 @default.
- W4206023390 cites W3134809801 @default.
- W4206023390 cites W4241617815 @default.
- W4206023390 doi "https://doi.org/10.1016/j.jff.2022.104934" @default.
- W4206023390 hasPublicationYear "2022" @default.
- W4206023390 type Work @default.
- W4206023390 citedByCount "4" @default.
- W4206023390 countsByYear W42060233902022 @default.
- W4206023390 countsByYear W42060233902023 @default.
- W4206023390 crossrefType "journal-article" @default.
- W4206023390 hasAuthorship W4206023390A5040899817 @default.
- W4206023390 hasAuthorship W4206023390A5041940361 @default.
- W4206023390 hasAuthorship W4206023390A5058555669 @default.
- W4206023390 hasAuthorship W4206023390A5059096816 @default.
- W4206023390 hasAuthorship W4206023390A5062896028 @default.
- W4206023390 hasAuthorship W4206023390A5068194594 @default.
- W4206023390 hasAuthorship W4206023390A5068954460 @default.