FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4206030661> ?p ?o ?g. }

• W4206030661 abstract "Serotonin receptors play central roles in neuromodulation and are critical drug targets for psychiatric disorders. Optical control of serotonin receptor subtypes has the potential to greatly enhance our understanding of the spatiotemporal dynamics of receptor function. While other neuromodulatory receptors have been successfully rendered photoswitchable, reversible photocontrol of serotonin receptors has not been achieved, representing a major gap in GPCR photopharmacology. Herein, we develop the first tools that allow for such control. Azo5HT-2 shows light-dependent 5-HT2A R agonism, with greater activity in the cis-form. Based on docking and test compound analysis, we also develop photoswitchable orthogonal, remotely-tethered ligands (PORTLs). These BG-Azo5HTs provide rapid, reversible, and repeatable optical control following conjugation to SNAP-tagged 5-HT2A R. Overall, this study provides a foundation for the broad extension of photopharmacology to the serotonin receptor family." @default.
• W4206030661 created "2022-01-26" @default.
• W4206030661 creator A5031211334 @default.
• W4206030661 creator A5042433434 @default.
• W4206030661 creator A5045527836 @default.
• W4206030661 creator A5052868074 @default.
• W4206030661 creator A5054607938 @default.
• W4206030661 creator A5054850069 @default.
• W4206030661 creator A5085347549 @default.
• W4206030661 date "2022-03-07" @default.
• W4206030661 modified "2023-10-16" @default.
• W4206030661 title "Photoswitchable Serotonins for Optical Control of the 5‐HT_2A Receptor**" @default.
• W4206030661 cites W1922677495 @default.
• W4206030661 cites W1946514915 @default.
• W4206030661 cites W2010812851 @default.
• W4206030661 cites W2011393168 @default.
• W4206030661 cites W2026393437 @default.
• W4206030661 cites W2078719550 @default.
• W4206030661 cites W2080123927 @default.
• W4206030661 cites W2095371774 @default.
• W4206030661 cites W2099456357 @default.
• W4206030661 cites W2114179830 @default.
• W4206030661 cites W2127884559 @default.
• W4206030661 cites W2135190897 @default.
• W4206030661 cites W2156790153 @default.
• W4206030661 cites W2293816282 @default.
• W4206030661 cites W2314098413 @default.
• W4206030661 cites W2326558292 @default.
• W4206030661 cites W2332727706 @default.
• W4206030661 cites W2342538606 @default.
• W4206030661 cites W2483686398 @default.
• W4206030661 cites W2519886147 @default.
• W4206030661 cites W2605869368 @default.
• W4206030661 cites W2606995352 @default.
• W4206030661 cites W2610875386 @default.
• W4206030661 cites W2615242172 @default.
• W4206030661 cites W2615853693 @default.
• W4206030661 cites W2683916252 @default.
• W4206030661 cites W2751759563 @default.
• W4206030661 cites W2768273624 @default.
• W4206030661 cites W2770696791 @default.
• W4206030661 cites W2792245061 @default.
• W4206030661 cites W2814854939 @default.
• W4206030661 cites W2911815863 @default.
• W4206030661 cites W2921734049 @default.
• W4206030661 cites W2922077267 @default.
• W4206030661 cites W2941312336 @default.
• W4206030661 cites W2942152627 @default.
• W4206030661 cites W2954544722 @default.
• W4206030661 cites W2991525008 @default.
• W4206030661 cites W3015140823 @default.
• W4206030661 cites W3030472127 @default.
• W4206030661 cites W3086773311 @default.
• W4206030661 cites W3093891609 @default.
• W4206030661 cites W3112535936 @default.
• W4206030661 cites W3118764283 @default.
• W4206030661 cites W3136820760 @default.
• W4206030661 cites W3157088173 @default.
• W4206030661 cites W3168098246 @default.
• W4206030661 cites W3179469168 @default.
• W4206030661 cites W3188595264 @default.
• W4206030661 cites W4211248987 @default.
• W4206030661 cites W4213001924 @default.
• W4206030661 cites W4233263784 @default.
• W4206030661 doi "https://doi.org/10.1002/anie.202117094" @default.
• W4206030661 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34989082" @default.
• W4206030661 hasPublicationYear "2022" @default.
• W4206030661 type Work @default.
• W4206030661 citedByCount "18" @default.
• W4206030661 countsByYear W42060306612022 @default.
• W4206030661 countsByYear W42060306612023 @default.
• W4206030661 crossrefType "journal-article" @default.
• W4206030661 hasAuthorship W4206030661A5031211334 @default.
• W4206030661 hasAuthorship W4206030661A5042433434 @default.
• W4206030661 hasAuthorship W4206030661A5045527836 @default.
• W4206030661 hasAuthorship W4206030661A5052868074 @default.
• W4206030661 hasAuthorship W4206030661A5054607938 @default.
• W4206030661 hasAuthorship W4206030661A5054850069 @default.
• W4206030661 hasAuthorship W4206030661A5085347549 @default.
• W4206030661 hasBestOaLocation W42060306612 @default.
• W4206030661 hasConcept C12554922 @default.
• W4206030661 hasConcept C135285700 @default.
• W4206030661 hasConcept C169760540 @default.
• W4206030661 hasConcept C170493617 @default.
• W4206030661 hasConcept C185592680 @default.
• W4206030661 hasConcept C2775864247 @default.
• W4206030661 hasConcept C2780375056 @default.
• W4206030661 hasConcept C53910766 @default.
• W4206030661 hasConcept C55493867 @default.
• W4206030661 hasConcept C86803240 @default.
• W4206030661 hasConceptScore W4206030661C12554922 @default.
• W4206030661 hasConceptScore W4206030661C135285700 @default.
• W4206030661 hasConceptScore W4206030661C169760540 @default.
• W4206030661 hasConceptScore W4206030661C170493617 @default.
• W4206030661 hasConceptScore W4206030661C185592680 @default.
• W4206030661 hasConceptScore W4206030661C2775864247 @default.
• W4206030661 hasConceptScore W4206030661C2780375056 @default.
• W4206030661 hasConceptScore W4206030661C53910766 @default.
• W4206030661 hasConceptScore W4206030661C55493867 @default.
• W4206030661 hasConceptScore W4206030661C86803240 @default.

• next