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- W4206033952 abstract "This chapter discusses the methods used for protecting industrial fermentation processes. Protection of various fermentation processes against contamination by means of antimicrobial agents has been capable of improving and economizing the fermentation process in a number of cases. In fermentations relatively insensitive to contaminations that are not carried out under aseptic conditions, the elimination of foreign microflora usually increases the yield of the metabolite produced. In aseptic fermentations, for example, in the production of antibiotics and similar biological preparations, a lowering of the number of batches usually discarded because of contamination can be expected besides a considerable simplification of the fermentation equipment. The current results have proved the practical possibility of the production of chlortetracycline without maintenance of aseptic conditions. Application of the protected fermentation of technical grade chlortetracycline proves especially advantageous in those cases where it is necessary to build up quickly a large production capacity because it makes possible the use of much simpler equipment than the usual stainless steel fermentation tanks with isolation sections, tightly fitting lids, and perfect stuffing boxes on impeller shafts." @default.
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- W4206033952 date "1959-01-01" @default.
- W4206033952 modified "2023-10-18" @default.
- W4206033952 title "Protected Fermentation" @default.
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- W4206033952 doi "https://doi.org/10.1016/s0065-2164(08)70472-6" @default.
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