FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4206035939> ?p ?o ?g. }

• W4206035939 abstract "The role of programmed cell death during embryonic development has been described previously, but its specific contribution to peri- and post-implantation stages is still debatable. Here, we used transmission electron microscopy and immunostaining of E5.5-7.5 mouse embryos to investigate death processes during these stages of development. We report that in addition to canonical apoptosis observed in E5.5-E7.5 embryos, a novel type of cell elimination occurs in E7.5 embryos among the epiblasts at the apical side, in which cells shed membrane-enclosed fragments of cytosol and organelles into the lumen, leaving behind small, enucleated cell remnants at the apical surface. This process is caspase-independent as it occurred in Apaf1 knockout embryos. We suggest that this novel mechanism controls epiblast cell numbers. Altogether, this work documents the activation of two distinct programs driving irreversible terminal states of epiblast cells in the post-implantation mouse embryo." @default.
• W4206035939 created "2022-01-25" @default.
• W4206035939 creator A5027776105 @default.
• W4206035939 creator A5047302954 @default.
• W4206035939 creator A5053012679 @default.
• W4206035939 creator A5063517445 @default.
• W4206035939 creator A5073557575 @default.
• W4206035939 date "2022-01-07" @default.
• W4206035939 modified "2023-10-14" @default.
• W4206035939 title "Epiblast fragmentation by shedding—a novel mechanism to eliminate cells in post-implantation mouse embryos" @default.
• W4206035939 cites W1501828659 @default.
• W4206035939 cites W1584232675 @default.
• W4206035939 cites W1871599003 @default.
• W4206035939 cites W1966492450 @default.
• W4206035939 cites W1976780320 @default.
• W4206035939 cites W1978423599 @default.
• W4206035939 cites W1979549057 @default.
• W4206035939 cites W2001562379 @default.
• W4206035939 cites W2003107854 @default.
• W4206035939 cites W2004550343 @default.
• W4206035939 cites W2005690646 @default.
• W4206035939 cites W2006159621 @default.
• W4206035939 cites W2010074919 @default.
• W4206035939 cites W2014190899 @default.
• W4206035939 cites W2024772624 @default.
• W4206035939 cites W2036492041 @default.
• W4206035939 cites W2044120077 @default.
• W4206035939 cites W2049873418 @default.
• W4206035939 cites W2061111373 @default.
• W4206035939 cites W2076069073 @default.
• W4206035939 cites W2087769305 @default.
• W4206035939 cites W2100705570 @default.
• W4206035939 cites W2116574982 @default.
• W4206035939 cites W2127375899 @default.
• W4206035939 cites W2134921841 @default.
• W4206035939 cites W2135330594 @default.
• W4206035939 cites W2146414105 @default.
• W4206035939 cites W2159861680 @default.
• W4206035939 cites W2233250281 @default.
• W4206035939 cites W2401788933 @default.
• W4206035939 cites W2406464272 @default.
• W4206035939 cites W2407099092 @default.
• W4206035939 cites W2518789018 @default.
• W4206035939 cites W3035578379 @default.
• W4206035939 cites W3089637349 @default.
• W4206035939 cites W3120805029 @default.
• W4206035939 cites W3135788257 @default.
• W4206035939 cites W3135852358 @default.
• W4206035939 cites W4298306231 @default.
• W4206035939 doi "https://doi.org/10.1038/s41418-021-00918-5" @default.
• W4206035939 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34992231" @default.
• W4206035939 hasPublicationYear "2022" @default.
• W4206035939 type Work @default.
• W4206035939 citedByCount "0" @default.
• W4206035939 crossrefType "journal-article" @default.
• W4206035939 hasAuthorship W4206035939A5027776105 @default.
• W4206035939 hasAuthorship W4206035939A5047302954 @default.
• W4206035939 hasAuthorship W4206035939A5053012679 @default.
• W4206035939 hasAuthorship W4206035939A5063517445 @default.
• W4206035939 hasAuthorship W4206035939A5073557575 @default.
• W4206035939 hasBestOaLocation W42060359391 @default.
• W4206035939 hasConcept C104317684 @default.
• W4206035939 hasConcept C129536746 @default.
• W4206035939 hasConcept C145103041 @default.
• W4206035939 hasConcept C190283241 @default.
• W4206035939 hasConcept C196843134 @default.
• W4206035939 hasConcept C203014093 @default.
• W4206035939 hasConcept C204232928 @default.
• W4206035939 hasConcept C31573885 @default.
• W4206035939 hasConcept C4224716 @default.
• W4206035939 hasConcept C54355233 @default.
• W4206035939 hasConcept C75059768 @default.
• W4206035939 hasConcept C86803240 @default.
• W4206035939 hasConcept C87073359 @default.
• W4206035939 hasConcept C95444343 @default.
• W4206035939 hasConceptScore W4206035939C104317684 @default.
• W4206035939 hasConceptScore W4206035939C129536746 @default.
• W4206035939 hasConceptScore W4206035939C145103041 @default.
• W4206035939 hasConceptScore W4206035939C190283241 @default.
• W4206035939 hasConceptScore W4206035939C196843134 @default.
• W4206035939 hasConceptScore W4206035939C203014093 @default.
• W4206035939 hasConceptScore W4206035939C204232928 @default.
• W4206035939 hasConceptScore W4206035939C31573885 @default.
• W4206035939 hasConceptScore W4206035939C4224716 @default.
• W4206035939 hasConceptScore W4206035939C54355233 @default.
• W4206035939 hasConceptScore W4206035939C75059768 @default.
• W4206035939 hasConceptScore W4206035939C86803240 @default.
• W4206035939 hasConceptScore W4206035939C87073359 @default.
• W4206035939 hasConceptScore W4206035939C95444343 @default.
• W4206035939 hasLocation W42060359391 @default.
• W4206035939 hasLocation W42060359392 @default.
• W4206035939 hasLocation W42060359393 @default.
• W4206035939 hasOpenAccess W4206035939 @default.
• W4206035939 hasPrimaryLocation W42060359391 @default.
• W4206035939 hasRelatedWork W119197021 @default.
• W4206035939 hasRelatedWork W161715053 @default.
• W4206035939 hasRelatedWork W2008530548 @default.
• W4206035939 hasRelatedWork W2151285117 @default.
• W4206035939 hasRelatedWork W2288872658 @default.
• W4206035939 hasRelatedWork W2560630996 @default.

• next