FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4206036024> ?p ?o ?g. }

• W4206036024 endingPage "66" @default.
• W4206036024 startingPage "53" @default.
• W4206036024 abstract "Prostate cancer (PC) is one of the major male malignancies worldwide. Because Na+-K+-ATPase is widely involved in various pathological processes, but the action of its α2 subtype (ATP1A2) in PC is unclear, we investigated the role of ATP1A2 in the invasion and migration of PC cells.We measured the expression levels of ATP1A2 in human normal prostate epithelial cell line (RWPE-1) and PC cell lines (PC-3 and DU145) by quantitative real-time PCR (qRT-PCR) and western blot. Cell proliferation, apoptosis, migration, and invasion of PC-3 and DU145 cells were investigated through clone formation assay, EdU assay, flow cytometry and transwell assay, respectively. The effect of ATP1A2 on a tumor-inhibitory pathway [transforming growth factor-β (TGF-β)/Smad] was assessed using western blot. In addition, tumor formation was detected using in vivo xenograft model in male BALB/c nude mice.The Cancer Genome Atlas (TCGA) analysis showed that ATP1A2 expression was reduced in PC patients (P<0.05), and patients with low ATP1A2 expression had a lower survival rate (P<0.05). ATP1A2 levels were significantly reduced in PC-3 and DU145 cells, compared with RWPE-1 cells (P<0.01). We also demonstrated that overexpression of ATP1A2 significantly inhibited the proliferation, migration, invasion, and epithelial-mesenchymal transition (EMT) of PC-3 and DU145 cells (P<0.01) and promoted apoptosis (P<0.01). However, silencing ATP1A2 had the opposite effect (P<0.01). In addition, overexpression of ATP1A2 significantly inhibited the TGF-β/Smad pathway (P<0.01), whereas silencing ATP1A2 activated the TGF-β/Smad pathway (P<0.01). Meanwhile, the effect of ATP1A2 silencing on the proliferation, apoptosis, migration and invasion was reversed by TGF-β/Smad pathway inhibitor (LY364947). Furthermore, ATP1A2 inhibited tumor growth in vivo.ATP1A2 inhibited proliferation, apoptosis, migration, invasion, and EMT in PC by inhibiting the TGF-β/Smad pathway." @default.
• W4206036024 created "2022-01-26" @default.
• W4206036024 creator A5005228021 @default.
• W4206036024 creator A5035652934 @default.
• W4206036024 creator A5066408207 @default.
• W4206036024 creator A5073969832 @default.
• W4206036024 creator A5081213141 @default.
• W4206036024 date "2022-01-01" @default.
• W4206036024 modified "2023-10-18" @default.
• W4206036024 title "Inhibition of the proliferation, invasion, migration, and epithelial-mesenchymal transition of prostate cancer cells through the action of ATP1A2 on the TGF-β/Smad pathway" @default.
• W4206036024 cites W1548022389 @default.
• W4206036024 cites W2009499235 @default.
• W4206036024 cites W2016360721 @default.
• W4206036024 cites W2028593825 @default.
• W4206036024 cites W2041299023 @default.
• W4206036024 cites W2050146329 @default.
• W4206036024 cites W2075023965 @default.
• W4206036024 cites W2124275925 @default.
• W4206036024 cites W2130229338 @default.
• W4206036024 cites W2283520462 @default.
• W4206036024 cites W2407506250 @default.
• W4206036024 cites W2412735479 @default.
• W4206036024 cites W2423859833 @default.
• W4206036024 cites W2570618306 @default.
• W4206036024 cites W2607145761 @default.
• W4206036024 cites W2618074111 @default.
• W4206036024 cites W2621206827 @default.
• W4206036024 cites W2786235194 @default.
• W4206036024 cites W2787236631 @default.
• W4206036024 cites W2789636189 @default.
• W4206036024 cites W2801878088 @default.
• W4206036024 cites W2802016913 @default.
• W4206036024 cites W2890411695 @default.
• W4206036024 cites W2904360942 @default.
• W4206036024 cites W2905560237 @default.
• W4206036024 cites W2909661552 @default.
• W4206036024 cites W2924150174 @default.
• W4206036024 cites W2931062553 @default.
• W4206036024 cites W2942683196 @default.
• W4206036024 cites W2951424539 @default.
• W4206036024 cites W2964889813 @default.
• W4206036024 cites W2976436811 @default.
• W4206036024 cites W2981396323 @default.
• W4206036024 cites W2989842006 @default.
• W4206036024 cites W2995517824 @default.
• W4206036024 cites W3009535588 @default.
• W4206036024 cites W3012708330 @default.
• W4206036024 cites W3095858614 @default.
• W4206036024 cites W3097168118 @default.
• W4206036024 cites W3109168381 @default.
• W4206036024 cites W3138649281 @default.
• W4206036024 cites W3156425342 @default.
• W4206036024 doi "https://doi.org/10.21037/tau-21-1117" @default.
• W4206036024 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35242641" @default.
• W4206036024 hasPublicationYear "2022" @default.
• W4206036024 type Work @default.
• W4206036024 citedByCount "2" @default.
• W4206036024 countsByYear W42060360242023 @default.
• W4206036024 crossrefType "journal-article" @default.
• W4206036024 hasAuthorship W4206036024A5005228021 @default.
• W4206036024 hasAuthorship W4206036024A5035652934 @default.
• W4206036024 hasAuthorship W4206036024A5066408207 @default.
• W4206036024 hasAuthorship W4206036024A5073969832 @default.
• W4206036024 hasAuthorship W4206036024A5081213141 @default.
• W4206036024 hasBestOaLocation W42060360241 @default.
• W4206036024 hasConcept C121608353 @default.
• W4206036024 hasConcept C126322002 @default.
• W4206036024 hasConcept C153911025 @default.
• W4206036024 hasConcept C185592680 @default.
• W4206036024 hasConcept C2776438761 @default.
• W4206036024 hasConcept C2779013556 @default.
• W4206036024 hasConcept C2779723316 @default.
• W4206036024 hasConcept C2780192828 @default.
• W4206036024 hasConcept C502942594 @default.
• W4206036024 hasConcept C54355233 @default.
• W4206036024 hasConcept C55493867 @default.
• W4206036024 hasConcept C62112901 @default.
• W4206036024 hasConcept C71924100 @default.
• W4206036024 hasConcept C76419328 @default.
• W4206036024 hasConcept C81885089 @default.
• W4206036024 hasConcept C86803240 @default.
• W4206036024 hasConceptScore W4206036024C121608353 @default.
• W4206036024 hasConceptScore W4206036024C126322002 @default.
• W4206036024 hasConceptScore W4206036024C153911025 @default.
• W4206036024 hasConceptScore W4206036024C185592680 @default.
• W4206036024 hasConceptScore W4206036024C2776438761 @default.
• W4206036024 hasConceptScore W4206036024C2779013556 @default.
• W4206036024 hasConceptScore W4206036024C2779723316 @default.
• W4206036024 hasConceptScore W4206036024C2780192828 @default.
• W4206036024 hasConceptScore W4206036024C502942594 @default.
• W4206036024 hasConceptScore W4206036024C54355233 @default.
• W4206036024 hasConceptScore W4206036024C55493867 @default.
• W4206036024 hasConceptScore W4206036024C62112901 @default.
• W4206036024 hasConceptScore W4206036024C71924100 @default.
• W4206036024 hasConceptScore W4206036024C76419328 @default.
• W4206036024 hasConceptScore W4206036024C81885089 @default.
• W4206036024 hasConceptScore W4206036024C86803240 @default.
• W4206036024 hasIssue "1" @default.

• next