Matches in SemOpenAlex for { <https://semopenalex.org/work/W4206036340> ?p ?o ?g. }
- W4206036340 endingPage "105248" @default.
- W4206036340 startingPage "105248" @default.
- W4206036340 abstract "Cathelicidins have been shown to effectively inhibit flavivirus replication in vitro. However, the effects of mouse and human endogenous cathelicidins on flavivirus infection in vivo are rarely known. We herein found that mouse endogenous cathelicidin CRAMP was significantly up-regulated upon Zika virus (ZIKV) infection. CRAMP deficiency markedly exacerbated ZIKV replication in testis, and aggravated ZIKV-induced testicular damage and spermatic damage in mice, indicating that endogenous cathelicidin is required for protection against ZIKV-caused male infertility in mice. In vitro antiviral assay showed that both mouse cathelidin CRAMP and human cathelicidin LL-37 obviously reduced ZIKV-caused cytopathic effect and inhibited ZIKV replication in Vero cells. Antiviral mechanism revealed that they both directly inactivated ZIKV virons by binding to ZIKV virons and inducing the leakage of ZIKV genomic RNA, consequently inactivated ZIKV virons. In vivo antiviral assay indicated that both of them effectively inhibited ZIKV replication in C57BL/6J and IFNα/β receptor-deficient (Ifnar1-/-) mice when CRAMP or LL-37 was intravenously injected in parallel with or at 1 h after intravenous injection of ZIKV, implying that CRAMP and LL-37 effectively inactivated ZIKV particles and exhibited therapeutic potential against ZIKV infection in vivo. Our findings reveal that endogenous cathelicidin CRAMP and LL-37 act as inactivators of ZIKV, and effectively protect against ZIKV replication and ZIKV-induced male infertility, highlighting their potential for therapy of ZIKV infection." @default.
- W4206036340 created "2022-01-26" @default.
- W4206036340 creator A5001568413 @default.
- W4206036340 creator A5014203739 @default.
- W4206036340 creator A5014894920 @default.
- W4206036340 creator A5024432704 @default.
- W4206036340 creator A5061119659 @default.
- W4206036340 creator A5071537189 @default.
- W4206036340 creator A5086595514 @default.
- W4206036340 creator A5091560656 @default.
- W4206036340 date "2022-02-01" @default.
- W4206036340 modified "2023-09-24" @default.
- W4206036340 title "Endogenous cathelicidin is required for protection against ZIKV-caused testis damage via inactivating virons" @default.
- W4206036340 cites W1645379154 @default.
- W4206036340 cites W1812571265 @default.
- W4206036340 cites W1877060350 @default.
- W4206036340 cites W1964758221 @default.
- W4206036340 cites W1966402088 @default.
- W4206036340 cites W1968200715 @default.
- W4206036340 cites W2023425836 @default.
- W4206036340 cites W2034280103 @default.
- W4206036340 cites W2040506631 @default.
- W4206036340 cites W2050242176 @default.
- W4206036340 cites W2053992388 @default.
- W4206036340 cites W2054602599 @default.
- W4206036340 cites W2056690166 @default.
- W4206036340 cites W2060483617 @default.
- W4206036340 cites W2079205719 @default.
- W4206036340 cites W2094237749 @default.
- W4206036340 cites W2096283909 @default.
- W4206036340 cites W2099382225 @default.
- W4206036340 cites W2106579717 @default.
- W4206036340 cites W2108763337 @default.
- W4206036340 cites W2120335030 @default.
- W4206036340 cites W2125861612 @default.
- W4206036340 cites W2129768982 @default.
- W4206036340 cites W2147852098 @default.
- W4206036340 cites W2165960748 @default.
- W4206036340 cites W2181140475 @default.
- W4206036340 cites W2193226117 @default.
- W4206036340 cites W2256096952 @default.
- W4206036340 cites W2267221707 @default.
- W4206036340 cites W2272004514 @default.
- W4206036340 cites W2285713692 @default.
- W4206036340 cites W2288668982 @default.
- W4206036340 cites W2289704315 @default.
- W4206036340 cites W2289738337 @default.
- W4206036340 cites W2423028299 @default.
- W4206036340 cites W2510187969 @default.
- W4206036340 cites W2510797894 @default.
- W4206036340 cites W2517345170 @default.
- W4206036340 cites W2553590861 @default.
- W4206036340 cites W2604885869 @default.
- W4206036340 cites W2739084511 @default.
- W4206036340 cites W2791036254 @default.
- W4206036340 cites W2885166080 @default.
- W4206036340 cites W2893827872 @default.
- W4206036340 cites W2897955299 @default.
- W4206036340 cites W2899705381 @default.
- W4206036340 cites W2911128628 @default.
- W4206036340 cites W2913979441 @default.
- W4206036340 cites W2936462194 @default.
- W4206036340 cites W2976040601 @default.
- W4206036340 cites W3009701390 @default.
- W4206036340 cites W3047459116 @default.
- W4206036340 cites W3121825748 @default.
- W4206036340 cites W3165904998 @default.
- W4206036340 cites W4253824931 @default.
- W4206036340 doi "https://doi.org/10.1016/j.antiviral.2022.105248" @default.
- W4206036340 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35038500" @default.
- W4206036340 hasPublicationYear "2022" @default.
- W4206036340 type Work @default.
- W4206036340 citedByCount "7" @default.
- W4206036340 countsByYear W42060363402022 @default.
- W4206036340 countsByYear W42060363402023 @default.
- W4206036340 crossrefType "journal-article" @default.
- W4206036340 hasAuthorship W4206036340A5001568413 @default.
- W4206036340 hasAuthorship W4206036340A5014203739 @default.
- W4206036340 hasAuthorship W4206036340A5014894920 @default.
- W4206036340 hasAuthorship W4206036340A5024432704 @default.
- W4206036340 hasAuthorship W4206036340A5061119659 @default.
- W4206036340 hasAuthorship W4206036340A5071537189 @default.
- W4206036340 hasAuthorship W4206036340A5086595514 @default.
- W4206036340 hasAuthorship W4206036340A5091560656 @default.
- W4206036340 hasConcept C134018914 @default.
- W4206036340 hasConcept C136449434 @default.
- W4206036340 hasConcept C140704245 @default.
- W4206036340 hasConcept C150903083 @default.
- W4206036340 hasConcept C159047783 @default.
- W4206036340 hasConcept C16613235 @default.
- W4206036340 hasConcept C203014093 @default.
- W4206036340 hasConcept C207001950 @default.
- W4206036340 hasConcept C2522874641 @default.
- W4206036340 hasConcept C2775996393 @default.
- W4206036340 hasConcept C2777053367 @default.
- W4206036340 hasConcept C2777379352 @default.
- W4206036340 hasConcept C2780568436 @default.
- W4206036340 hasConcept C86803240 @default.