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- W4206043779 abstract "Extracts of Hibiscus sabdariffa L. (commonly called Rosselle or Jamaica flower in Mexico) have been shown to have antibiotic and antivirulence properties in several bacteria. Here, an organic extract of H. sabdariffa L. is shown to inhibit motility in Salmonella enterica serovars Typhi and Typhimurium. The compound responsible for this effect was purified and found to be the hibiscus acid. When tested, this compound also inhibited motility and reduced the secretion of both flagellin and type III secretion effectors. Purified hibiscus acid was not toxic in tissue-cultured eukaryotic cells, and it was able to reduce the invasion of Salmonella Typhimurium in epithelial cells. Initial steps to understand its mode of action showed it might affect membrane proton balance." @default.
- W4206043779 created "2022-01-25" @default.
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- W4206043779 date "2022-01-20" @default.
- W4206043779 modified "2023-10-18" @default.
- W4206043779 title "Hibiscus Acid from Hibiscus sabdariffa L. Inhibits Flagellar Motility and Cell Invasion in Salmonella enterica" @default.
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- W4206043779 doi "https://doi.org/10.3390/molecules27030655" @default.
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