Matches in SemOpenAlex for { <https://semopenalex.org/work/W4206048163> ?p ?o ?g. }
- W4206048163 endingPage "174593" @default.
- W4206048163 startingPage "174593" @default.
- W4206048163 abstract "Colorectal cancer (CRC) is considered the second most frequent cancer globally and one of the deadliest malignancies in humans. On the other hand, over time and facing the challenges of cancer treatment, several therapeutic approaches, including surgery, radiotherapy, chemotherapy, and immunotherapy, are being developed. Evidence showed that combination therapies had given relatively satisfactory clinical outcomes in inhibiting tumor progression and increasing patient survival compared with monotherapy. Among the available compounds and drugs used in chemotherapy, doxycycline, an antimicrobial drug, has been suitable for treating several malignancies such as CRC. It has been revealed that doxycycline has anti-tumor properties and can help control tumor growth in various mechanisms, such as inhibiting anti-apoptotic and angiogenic proteins. In addition, studies have shown that combination therapy with doxycycline and other anti-tumor drugs, such as doxorubicin, anti-angiogenic factors, and anti-check-point blockers, can inhibit tumor progression. Therefore, this review summarized the anti-tumor mechanisms of doxycycline in CRC treatment and related combination therapies." @default.
- W4206048163 created "2022-01-26" @default.
- W4206048163 creator A5026890276 @default.
- W4206048163 creator A5083361329 @default.
- W4206048163 date "2022-02-01" @default.
- W4206048163 modified "2023-10-12" @default.
- W4206048163 title "A Brief look at antitumor effects of doxycycline in the treatment of colorectal cancer and combination therapies" @default.
- W4206048163 cites W1533021978 @default.
- W4206048163 cites W1574172480 @default.
- W4206048163 cites W1594203091 @default.
- W4206048163 cites W1762083827 @default.
- W4206048163 cites W1944656365 @default.
- W4206048163 cites W1967600348 @default.
- W4206048163 cites W1978186598 @default.
- W4206048163 cites W1985538633 @default.
- W4206048163 cites W1987912339 @default.
- W4206048163 cites W1988924112 @default.
- W4206048163 cites W1988967958 @default.
- W4206048163 cites W1995249913 @default.
- W4206048163 cites W2001258296 @default.
- W4206048163 cites W2001485008 @default.
- W4206048163 cites W2015025178 @default.
- W4206048163 cites W2017322644 @default.
- W4206048163 cites W2023907959 @default.
- W4206048163 cites W2034343829 @default.
- W4206048163 cites W2034667960 @default.
- W4206048163 cites W2035639577 @default.
- W4206048163 cites W2042734448 @default.
- W4206048163 cites W2044905529 @default.
- W4206048163 cites W2046657016 @default.
- W4206048163 cites W2048932155 @default.
- W4206048163 cites W2053204557 @default.
- W4206048163 cites W2071786518 @default.
- W4206048163 cites W2073538859 @default.
- W4206048163 cites W2080372436 @default.
- W4206048163 cites W2088153666 @default.
- W4206048163 cites W2093070846 @default.
- W4206048163 cites W2115474596 @default.
- W4206048163 cites W2123293350 @default.
- W4206048163 cites W2134000233 @default.
- W4206048163 cites W2134542375 @default.
- W4206048163 cites W2140088548 @default.
- W4206048163 cites W2146565047 @default.
- W4206048163 cites W2151591273 @default.
- W4206048163 cites W2157492231 @default.
- W4206048163 cites W2176095157 @default.
- W4206048163 cites W2239705084 @default.
- W4206048163 cites W2310996388 @default.
- W4206048163 cites W2325707043 @default.
- W4206048163 cites W2326347820 @default.
- W4206048163 cites W2338994579 @default.
- W4206048163 cites W2343144688 @default.
- W4206048163 cites W2419535666 @default.
- W4206048163 cites W2538151572 @default.
- W4206048163 cites W2550772903 @default.
- W4206048163 cites W2576899770 @default.
- W4206048163 cites W2586731249 @default.
- W4206048163 cites W2586777370 @default.
- W4206048163 cites W2591693584 @default.
- W4206048163 cites W2595800590 @default.
- W4206048163 cites W2621801544 @default.
- W4206048163 cites W2749336010 @default.
- W4206048163 cites W2752528156 @default.
- W4206048163 cites W2754172081 @default.
- W4206048163 cites W2765417842 @default.
- W4206048163 cites W2766425483 @default.
- W4206048163 cites W2779045233 @default.
- W4206048163 cites W2791503638 @default.
- W4206048163 cites W2792013016 @default.
- W4206048163 cites W2792453555 @default.
- W4206048163 cites W2803416433 @default.
- W4206048163 cites W2885190696 @default.
- W4206048163 cites W2897148138 @default.
- W4206048163 cites W2898306498 @default.
- W4206048163 cites W2898686319 @default.
- W4206048163 cites W2905056664 @default.
- W4206048163 cites W2913389688 @default.
- W4206048163 cites W2941280883 @default.
- W4206048163 cites W3004759815 @default.
- W4206048163 cites W3010591636 @default.
- W4206048163 cites W3023233752 @default.
- W4206048163 cites W3035223304 @default.
- W4206048163 cites W3094755980 @default.
- W4206048163 cites W3103933344 @default.
- W4206048163 cites W3111817441 @default.
- W4206048163 cites W3120698289 @default.
- W4206048163 cites W3195280542 @default.
- W4206048163 cites W4211238487 @default.
- W4206048163 cites W4237191081 @default.
- W4206048163 cites W2165506042 @default.
- W4206048163 doi "https://doi.org/10.1016/j.ejphar.2021.174593" @default.
- W4206048163 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34973952" @default.
- W4206048163 hasPublicationYear "2022" @default.
- W4206048163 type Work @default.
- W4206048163 citedByCount "7" @default.
- W4206048163 countsByYear W42060481632022 @default.
- W4206048163 countsByYear W42060481632023 @default.
- W4206048163 crossrefType "journal-article" @default.