Matches in SemOpenAlex for { <https://semopenalex.org/work/W4206048897> ?p ?o ?g. }
- W4206048897 abstract "Counteracting innate immunity is essential for successful viral replication. Host cyclophilins (Cyps) have been implicated in viral evasion of host antiviral responses, although the mechanisms are still unclear. Here, we show that hepatitis C virus (HCV) co-opts the host protein CypA to aid evasion of antiviral responses dependent on the effector protein kinase R (PKR). Pharmacological inhibition of CypA rescues PKR from antagonism by HCV NS5A, leading to activation of an interferon regulatory factor-1 (IRF1)-driven cell intrinsic antiviral program that inhibits viral replication. These findings further the understanding of the complexity of Cyp-virus interactions, provide mechanistic insight into the remarkably broad antiviral spectrum of Cyp inhibitors, and uncover novel aspects of PKR activity and regulation. Collectively, our study identifies a novel antiviral mechanism that harnesses cellular antiviral immunity to suppress viral replication." @default.
- W4206048897 created "2022-01-26" @default.
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- W4206048897 date "2020-06-16" @default.
- W4206048897 modified "2023-10-14" @default.
- W4206048897 title "Hepatitis C virus exploits cyclophilin A to evade PKR" @default.
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- W4206048897 doi "https://doi.org/10.7554/elife.52237" @default.
- W4206048897 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32539931" @default.
- W4206048897 hasPublicationYear "2020" @default.
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