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- W4206056384 abstract "We describe a system that permits the automated analysis of reporter gene expression in Caenorhabditis elegans with cellular resolution continuously during embryogenesis. We demonstrate its utility by defining the expression patterns of reporters for several embryonically expressed transcription factors. The invariant cell lineage permits the automated alignment of multiple expression profiles, allowing direct comparison of the expression of different genes' reporters. We also used this system to monitor perturbations to normal development involving changes both in cell-division timing and in cell fate. Systematic application of this system could reveal the gene activity of each cell throughout development. PMID: 18587405 Funding information This work was supported by: NIGMS NIH HHS, United States Grant ID: R01 GM072675-04 NIGMS NIH HHS, United States Grant ID: R01 GM072675 NIGMS NIH HHS, United States Grant ID: K99 GM083145-01 NIGMS NIH HHS, United States Grant ID: K99 GM083145" @default.
- W4206056384 created "2022-01-25" @default.
- W4206056384 creator A5017332761 @default.
- W4206056384 date "2008-09-10" @default.
- W4206056384 modified "2023-09-27" @default.
- W4206056384 title "Faculty Opinions recommendation of Automated analysis of embryonic gene expression with cellular resolution in C. elegans." @default.
- W4206056384 doi "https://doi.org/10.3410/f.1119583.575800" @default.
- W4206056384 hasPublicationYear "2008" @default.
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