FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4206068971> ?p ?o ?g. }

• W4206068971 endingPage "400" @default.
• W4206068971 startingPage "385" @default.
• W4206068971 abstract "• Pharmacological recommendations for augmentation treatments in depression have been controversial. • Our findings support the use of atypical antipsychotics, lithium, thyroid hormones, modafinil, lisdexamfetamine, as effective augmentation agents. • Lithium and thyroid hormones constitute an important augmentation strategy in the general pharmacopeia for TRD despite being overly underutilized. • Pharmacological recommendations should outweigh the potential risk and benefits in the context of side-effect burden and patients’ preference to ameliorate depressive symptoms. To compare the efficacy and discontinuation of augmentation agents in adult patients with treatment-resistant depression (TRD). We conducted a systematic review and network meta-analyses (NMA) to combine direct and indirect comparisons of augmentation agents. We included randomized controlled trials comparing one active drug with another or with placebo following a treatment course up to 24 weeks. Nineteen agents were included: stimulants, atypical antipsychotics, thyroid hormones, antidepressants, and mood stabilizers. Data for response/remission and all-cause discontinuation rates were analyzed. We estimated effect-size by relative risk using pairwise and NMA with random-effects model. A total of 65 studies ( N = 12,415) with 19 augmentation agents were included in the NMA. Our findings from the NMA for response rates, compared to placebo, were significant for: liothyronine, nortriptyline, aripiprazole, brexpiprazole, quetiapine, lithium, modafinil, olanzapine (fluoxetine), cariprazine, and lisdexamfetamine. For remission rates, compared to placebo, were significant for: thyroid hormone(T4), aripiprazole, brexpiprazole, risperidone, quetiapine, and olanzapine (fluoxetine). Compared to placebo, ziprasidone, mirtazapine, and cariprazine had statistically significant higher discontinuation rates. Overall, 24% studies were rated as having low risk of bias (RoB), 63% had moderate RoB and 13% had high RoB. Heterogeneity in TRD definitions, variable trial duration and methodological clinical design of older studies and small number of trials per comparisons. This NMA suggests a superiority of the regulatory approved adjunctive atypical antipsychotics, thyroid hormones, dopamine compounds (modafinil and lisdexamfetamine) and lithium. Acceptability was lower with ziprasidone, mirtazapine, and cariprazine. Further research and head-to-head studies should be considered to strengthen the best available options for TRD." @default.
• W4206068971 created "2022-01-26" @default.
• W4206068971 creator A5021182139 @default.
• W4206068971 creator A5029433360 @default.
• W4206068971 creator A5036093248 @default.
• W4206068971 creator A5038312444 @default.
• W4206068971 creator A5039884481 @default.
• W4206068971 creator A5050515785 @default.
• W4206068971 creator A5065058975 @default.
• W4206068971 creator A5065541238 @default.
• W4206068971 creator A5067637091 @default.
• W4206068971 creator A5073495332 @default.
• W4206068971 creator A5076427138 @default.
• W4206068971 creator A5081972371 @default.
• W4206068971 date "2022-04-01" @default.
• W4206068971 modified "2023-10-16" @default.
• W4206068971 title "Augmentation strategies for treatment resistant major depression: A systematic review and network meta-analysis" @default.
• W4206068971 cites W1607918370 @default.
• W4206068971 cites W1868790909 @default.
• W4206068971 cites W1893611463 @default.
• W4206068971 cites W1937474893 @default.
• W4206068971 cites W1964435302 @default.
• W4206068971 cites W1966000564 @default.
• W4206068971 cites W1966942082 @default.
• W4206068971 cites W1979281142 @default.
• W4206068971 cites W1980153964 @default.
• W4206068971 cites W1983900457 @default.
• W4206068971 cites W1984052858 @default.
• W4206068971 cites W1985086901 @default.
• W4206068971 cites W1985193354 @default.
• W4206068971 cites W1986803960 @default.
• W4206068971 cites W1987459299 @default.
• W4206068971 cites W1988049829 @default.
• W4206068971 cites W1990651253 @default.
• W4206068971 cites W1991497633 @default.
• W4206068971 cites W1995667504 @default.
• W4206068971 cites W1995777506 @default.
• W4206068971 cites W2002118034 @default.
• W4206068971 cites W2003982930 @default.
• W4206068971 cites W2007880575 @default.
• W4206068971 cites W2012655610 @default.
• W4206068971 cites W2013457279 @default.
• W4206068971 cites W2014577629 @default.
• W4206068971 cites W2017663874 @default.
• W4206068971 cites W2020739757 @default.
• W4206068971 cites W2020924268 @default.
• W4206068971 cites W2021939430 @default.
• W4206068971 cites W2024457073 @default.
• W4206068971 cites W2025953646 @default.
• W4206068971 cites W2029670923 @default.
• W4206068971 cites W2031799297 @default.
• W4206068971 cites W2033726468 @default.
• W4206068971 cites W2034750014 @default.
• W4206068971 cites W2038119785 @default.
• W4206068971 cites W2040557955 @default.
• W4206068971 cites W2042982960 @default.
• W4206068971 cites W2043871213 @default.
• W4206068971 cites W2049695419 @default.
• W4206068971 cites W2050386004 @default.
• W4206068971 cites W2051933342 @default.
• W4206068971 cites W2052168906 @default.
• W4206068971 cites W2055629924 @default.
• W4206068971 cites W2058458012 @default.
• W4206068971 cites W2058805315 @default.
• W4206068971 cites W2062017119 @default.
• W4206068971 cites W2064106647 @default.
• W4206068971 cites W2064478935 @default.
• W4206068971 cites W2065791141 @default.
• W4206068971 cites W2067314968 @default.
• W4206068971 cites W2068927187 @default.
• W4206068971 cites W2070007822 @default.
• W4206068971 cites W2070828096 @default.
• W4206068971 cites W2073585506 @default.
• W4206068971 cites W2075635987 @default.
• W4206068971 cites W2078154303 @default.
• W4206068971 cites W2079804712 @default.
• W4206068971 cites W2082611363 @default.
• W4206068971 cites W2083597120 @default.
• W4206068971 cites W2085805157 @default.
• W4206068971 cites W2093300144 @default.
• W4206068971 cites W2098923148 @default.
• W4206068971 cites W2104518967 @default.
• W4206068971 cites W2107328434 @default.
• W4206068971 cites W2114693958 @default.
• W4206068971 cites W2119052059 @default.
• W4206068971 cites W2120285083 @default.
• W4206068971 cites W2121363983 @default.
• W4206068971 cites W2122016047 @default.
• W4206068971 cites W2122681119 @default.
• W4206068971 cites W2125094332 @default.
• W4206068971 cites W2125435699 @default.
• W4206068971 cites W2129821518 @default.
• W4206068971 cites W2132324173 @default.
• W4206068971 cites W2139168999 @default.
• W4206068971 cites W2140725933 @default.
• W4206068971 cites W2142561755 @default.
• W4206068971 cites W2143091287 @default.
• W4206068971 cites W2155959499 @default.

• next