Matches in SemOpenAlex for { <https://semopenalex.org/work/W4206087013> ?p ?o ?g. }
Showing items 1 to 100 of
100
with 100 items per page.
- W4206087013 abstract "ABSTRACT Septins are a family of cytoskeletal proteins that regulate several important aspects of neuronal development. Septin 7 (Sept7) is enriched at the base of dendritic spines in excitatory neurons and mediates both spine formation and spine-synapse maturation. Phosphorylation at a conserved C-terminal tail residue of Sept7 mediates its translocation into the dendritic spine head to allow spine-synapse maturation. The mechanistic basis for postsynaptic stability and compartmentalization conferred by phosphorylated Sept7, however, is not known. We report herein the proteomic identification of Sept7 phosphorylation dependent neuronal interactors. Using Sept7 C-terminal phosphopeptide pulldown and biochemical assays, we show that the 14-3-3 family of proteins specifically interact with Sept7 when phosphorylated at the T426 residue. Biochemically, we validate the interaction between Sept7 and 14-3-3 isoform gamma, and show that 14-3-3 gamma is also enriched in mature dendritic spine head. Further, we demonstrate that interaction of phosphorylated Sept7 with 14-3-3 protects it from dephosphorylation, as expression of a 14-3-3 antagonist significantly decreases phosphorylated Sept7 in neurons. This study identifies 14-3-3 proteins as an important physiological regulator of Sept7 function in neuronal development." @default.
- W4206087013 created "2022-01-26" @default.
- W4206087013 creator A5006714818 @default.
- W4206087013 creator A5020764752 @default.
- W4206087013 creator A5028847313 @default.
- W4206087013 creator A5043434220 @default.
- W4206087013 creator A5044875949 @default.
- W4206087013 creator A5046251137 @default.
- W4206087013 creator A5084523317 @default.
- W4206087013 date "2022-01-04" @default.
- W4206087013 modified "2023-09-27" @default.
- W4206087013 title "Proteomic identification of phosphorylation dependent Septin 7 interactors that drive dendritic spine formation" @default.
- W4206087013 cites W1969651353 @default.
- W4206087013 cites W1976728998 @default.
- W4206087013 cites W1985805440 @default.
- W4206087013 cites W1988476536 @default.
- W4206087013 cites W2003629016 @default.
- W4206087013 cites W2003949450 @default.
- W4206087013 cites W2004451728 @default.
- W4206087013 cites W2006018605 @default.
- W4206087013 cites W2010752097 @default.
- W4206087013 cites W2025098596 @default.
- W4206087013 cites W2026364178 @default.
- W4206087013 cites W2026856916 @default.
- W4206087013 cites W2030842017 @default.
- W4206087013 cites W2044450732 @default.
- W4206087013 cites W2046284005 @default.
- W4206087013 cites W2048374819 @default.
- W4206087013 cites W2072529095 @default.
- W4206087013 cites W2076314401 @default.
- W4206087013 cites W2078116784 @default.
- W4206087013 cites W2079724117 @default.
- W4206087013 cites W2106791925 @default.
- W4206087013 cites W2117333689 @default.
- W4206087013 cites W2164863856 @default.
- W4206087013 cites W2461115402 @default.
- W4206087013 cites W2570293024 @default.
- W4206087013 cites W2763357161 @default.
- W4206087013 cites W3153833007 @default.
- W4206087013 cites W3171418572 @default.
- W4206087013 cites W4243411621 @default.
- W4206087013 doi "https://doi.org/10.1101/2022.01.04.474970" @default.
- W4206087013 hasPublicationYear "2022" @default.
- W4206087013 type Work @default.
- W4206087013 citedByCount "1" @default.
- W4206087013 countsByYear W42060870132023 @default.
- W4206087013 crossrefType "posted-content" @default.
- W4206087013 hasAuthorship W4206087013A5006714818 @default.
- W4206087013 hasAuthorship W4206087013A5020764752 @default.
- W4206087013 hasAuthorship W4206087013A5028847313 @default.
- W4206087013 hasAuthorship W4206087013A5043434220 @default.
- W4206087013 hasAuthorship W4206087013A5044875949 @default.
- W4206087013 hasAuthorship W4206087013A5046251137 @default.
- W4206087013 hasAuthorship W4206087013A5084523317 @default.
- W4206087013 hasBestOaLocation W42060870131 @default.
- W4206087013 hasConcept C11960822 @default.
- W4206087013 hasConcept C148762608 @default.
- W4206087013 hasConcept C1491633281 @default.
- W4206087013 hasConcept C169760540 @default.
- W4206087013 hasConcept C174884520 @default.
- W4206087013 hasConcept C178666793 @default.
- W4206087013 hasConcept C179411191 @default.
- W4206087013 hasConcept C181912034 @default.
- W4206087013 hasConcept C185592680 @default.
- W4206087013 hasConcept C45472230 @default.
- W4206087013 hasConcept C55493867 @default.
- W4206087013 hasConcept C85813293 @default.
- W4206087013 hasConcept C86803240 @default.
- W4206087013 hasConcept C95444343 @default.
- W4206087013 hasConceptScore W4206087013C11960822 @default.
- W4206087013 hasConceptScore W4206087013C148762608 @default.
- W4206087013 hasConceptScore W4206087013C1491633281 @default.
- W4206087013 hasConceptScore W4206087013C169760540 @default.
- W4206087013 hasConceptScore W4206087013C174884520 @default.
- W4206087013 hasConceptScore W4206087013C178666793 @default.
- W4206087013 hasConceptScore W4206087013C179411191 @default.
- W4206087013 hasConceptScore W4206087013C181912034 @default.
- W4206087013 hasConceptScore W4206087013C185592680 @default.
- W4206087013 hasConceptScore W4206087013C45472230 @default.
- W4206087013 hasConceptScore W4206087013C55493867 @default.
- W4206087013 hasConceptScore W4206087013C85813293 @default.
- W4206087013 hasConceptScore W4206087013C86803240 @default.
- W4206087013 hasConceptScore W4206087013C95444343 @default.
- W4206087013 hasLocation W42060870131 @default.
- W4206087013 hasLocation W42060870132 @default.
- W4206087013 hasOpenAccess W4206087013 @default.
- W4206087013 hasPrimaryLocation W42060870131 @default.
- W4206087013 hasRelatedWork W1966455810 @default.
- W4206087013 hasRelatedWork W1967655002 @default.
- W4206087013 hasRelatedWork W1985797917 @default.
- W4206087013 hasRelatedWork W2116721774 @default.
- W4206087013 hasRelatedWork W2117333689 @default.
- W4206087013 hasRelatedWork W2237126255 @default.
- W4206087013 hasRelatedWork W2317452501 @default.
- W4206087013 hasRelatedWork W2800492132 @default.
- W4206087013 hasRelatedWork W4206087013 @default.
- W4206087013 hasRelatedWork W4225418340 @default.
- W4206087013 isParatext "false" @default.
- W4206087013 isRetracted "false" @default.
- W4206087013 workType "article" @default.