FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4206088564> ?p ?o ?g. }

• W4206088564 abstract "Tissue engineering offers a promising treatment strategy for ureteral strictures, but its success requires an in-depth understanding of the architecture, cellular heterogeneity, and signaling pathways underlying tissue regeneration. Here we define and spatially map cell populations within the human ureter using single-cell RNA sequencing, spatial gene expression, and immunofluorescence approaches. We focused on the stromal and urothelial cell populations to enumerate distinct cell types composing the human ureter and inferred potential cell-cell communication networks underpinning the bi-directional crosstalk between these compartments. Furthermore, we analyzed and experimentally validated the importance of Sonic Hedgehog (SHH) signaling pathway in adult stem cell maintenance. The SHH-expressing basal cells supported organoid generation in vitro and accurately predicted the differentiation trajectory from basal stem cells to terminally differentiated umbrella cells. Our results highlight essential processes involved in adult ureter tissue homeostasis and provide a blueprint for guiding ureter tissue engineering." @default.
• W4206088564 created "2022-01-26" @default.
• W4206088564 creator A5001008253 @default.
• W4206088564 creator A5012052290 @default.
• W4206088564 creator A5016306089 @default.
• W4206088564 creator A5020575520 @default.
• W4206088564 creator A5021136675 @default.
• W4206088564 creator A5026611664 @default.
• W4206088564 creator A5027100096 @default.
• W4206088564 creator A5047015569 @default.
• W4206088564 creator A5050601416 @default.
• W4206088564 creator A5055217733 @default.
• W4206088564 creator A5069069312 @default.
• W4206088564 creator A5070471092 @default.
• W4206088564 creator A5081608960 @default.
• W4206088564 creator A5084946665 @default.
• W4206088564 creator A5086350104 @default.
• W4206088564 date "2021-12-23" @default.
• W4206088564 modified "2023-10-07" @default.
• W4206088564 title "Ureter single-cell and spatial mapping reveal cell types, architecture, and signaling networks" @default.
• W4206088564 doi "https://doi.org/10.1101/2021.12.22.473889" @default.
• W4206088564 hasPublicationYear "2021" @default.
• W4206088564 type Work @default.
• W4206088564 citedByCount "0" @default.
• W4206088564 crossrefType "posted-content" @default.
• W4206088564 hasAuthorship W4206088564A5001008253 @default.
• W4206088564 hasAuthorship W4206088564A5012052290 @default.
• W4206088564 hasAuthorship W4206088564A5016306089 @default.
• W4206088564 hasAuthorship W4206088564A5020575520 @default.
• W4206088564 hasAuthorship W4206088564A5021136675 @default.
• W4206088564 hasAuthorship W4206088564A5026611664 @default.
• W4206088564 hasAuthorship W4206088564A5027100096 @default.
• W4206088564 hasAuthorship W4206088564A5047015569 @default.
• W4206088564 hasAuthorship W4206088564A5050601416 @default.
• W4206088564 hasAuthorship W4206088564A5055217733 @default.
• W4206088564 hasAuthorship W4206088564A5069069312 @default.
• W4206088564 hasAuthorship W4206088564A5070471092 @default.
• W4206088564 hasAuthorship W4206088564A5081608960 @default.
• W4206088564 hasAuthorship W4206088564A5084946665 @default.
• W4206088564 hasAuthorship W4206088564A5086350104 @default.
• W4206088564 hasBestOaLocation W42060885641 @default.
• W4206088564 hasConcept C104317684 @default.
• W4206088564 hasConcept C105702510 @default.
• W4206088564 hasConcept C120665830 @default.
• W4206088564 hasConcept C121332964 @default.
• W4206088564 hasConcept C126894567 @default.
• W4206088564 hasConcept C148738053 @default.
• W4206088564 hasConcept C1491633281 @default.
• W4206088564 hasConcept C163952510 @default.
• W4206088564 hasConcept C16930146 @default.
• W4206088564 hasConcept C169822122 @default.
• W4206088564 hasConcept C189014844 @default.
• W4206088564 hasConcept C2776637008 @default.
• W4206088564 hasConcept C2776664737 @default.
• W4206088564 hasConcept C2777540882 @default.
• W4206088564 hasConcept C28328180 @default.
• W4206088564 hasConcept C2910041100 @default.
• W4206088564 hasConcept C502942594 @default.
• W4206088564 hasConcept C54355233 @default.
• W4206088564 hasConcept C62478195 @default.
• W4206088564 hasConcept C71924100 @default.
• W4206088564 hasConcept C77411442 @default.
• W4206088564 hasConcept C86339819 @default.
• W4206088564 hasConcept C86803240 @default.
• W4206088564 hasConcept C95444343 @default.
• W4206088564 hasConceptScore W4206088564C104317684 @default.
• W4206088564 hasConceptScore W4206088564C105702510 @default.
• W4206088564 hasConceptScore W4206088564C120665830 @default.
• W4206088564 hasConceptScore W4206088564C121332964 @default.
• W4206088564 hasConceptScore W4206088564C126894567 @default.
• W4206088564 hasConceptScore W4206088564C148738053 @default.
• W4206088564 hasConceptScore W4206088564C1491633281 @default.
• W4206088564 hasConceptScore W4206088564C163952510 @default.
• W4206088564 hasConceptScore W4206088564C16930146 @default.
• W4206088564 hasConceptScore W4206088564C169822122 @default.
• W4206088564 hasConceptScore W4206088564C189014844 @default.
• W4206088564 hasConceptScore W4206088564C2776637008 @default.
• W4206088564 hasConceptScore W4206088564C2776664737 @default.
• W4206088564 hasConceptScore W4206088564C2777540882 @default.
• W4206088564 hasConceptScore W4206088564C28328180 @default.
• W4206088564 hasConceptScore W4206088564C2910041100 @default.
• W4206088564 hasConceptScore W4206088564C502942594 @default.
• W4206088564 hasConceptScore W4206088564C54355233 @default.
• W4206088564 hasConceptScore W4206088564C62478195 @default.
• W4206088564 hasConceptScore W4206088564C71924100 @default.
• W4206088564 hasConceptScore W4206088564C77411442 @default.
• W4206088564 hasConceptScore W4206088564C86339819 @default.
• W4206088564 hasConceptScore W4206088564C86803240 @default.
• W4206088564 hasConceptScore W4206088564C95444343 @default.
• W4206088564 hasLocation W42060885641 @default.
• W4206088564 hasOpenAccess W4206088564 @default.
• W4206088564 hasPrimaryLocation W42060885641 @default.
• W4206088564 hasRelatedWork W1972761890 @default.
• W4206088564 hasRelatedWork W2003499218 @default.
• W4206088564 hasRelatedWork W2033029606 @default.
• W4206088564 hasRelatedWork W2053628391 @default.
• W4206088564 hasRelatedWork W2111214065 @default.
• W4206088564 hasRelatedWork W2137371313 @default.
• W4206088564 hasRelatedWork W4200534947 @default.
• W4206088564 hasRelatedWork W4206088564 @default.

• next