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- W4206103638 abstract "A new dinuclear cyclic gold(I) complex [Au2(DCyPA)2](PF6)2, 1, based on bis[2-(dicyclohexylphosphano)ethyl]amine (DCyPA) has been synthesized and characterized by elemental analysis, IR and NMR spectroscopy, and X-ray crystallography. In the dinuclear complex cation [Au2(DCyPA)2]2+, the two gold(I) ions are bridged by the ligand bis[2-(dicyclohexylphosphano)ethyl]amine (DCyPA) giving rise to a 16-membered ring centrosymmetric metallacycle. The cytotoxicity of the complex was evaluated against the triple-negative human breast cancer cells MDA-MB-231. In order to understand the mechanism of the cytotoxic behavior, a variety of assays, including Annexin V-FITC/Propidium iodide double staining, ROS production, and mitochondrial membrane potential and migration assays were carried out. The results indicated that complex 1 induced cytotoxicity via an oxidative stress-mediated intrinsic apoptotic pathway in MDA-MB-231 cancer cells." @default.
- W4206103638 created "2022-01-26" @default.
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- W4206103638 date "2022-01-01" @default.
- W4206103638 modified "2023-10-01" @default.
- W4206103638 title "A novel cyclic dinuclear gold(<scp>i</scp>) complex induces anticancer activity <i>via</i> an oxidative stress-mediated intrinsic apoptotic pathway in MDA-MB-231 cancer cells" @default.
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- W4206103638 doi "https://doi.org/10.1039/d1dt03546k" @default.
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