Matches in SemOpenAlex for { <https://semopenalex.org/work/W4206103887> ?p ?o ?g. }
- W4206103887 endingPage "17267" @default.
- W4206103887 startingPage "17260" @default.
- W4206103887 abstract "Abstract Werner's Complex, as a cationic coordination complex (CCC), has hitherto unappreciated biological properties derived from its binding affinity to highly anionic biomolecules such as glycosaminoglycans (GAGs) and nucleic acids. Competitive inhibitor and spectroscopic assays confirm the high affinity to GAGs heparin, heparan sulfate (HS), and its pentasaccharide mimetic Fondaparinux (FPX). Functional consequences of this affinity include inhibition of FPX cleavage by bacterial heparinase and mammalian heparanase enzymes with inhibition of cellular invasion and migration. Werner's Complex is a very efficient condensing agent for DNA and tRNA. In proof‐of‐principle for translational implications, it is demonstrated to display antiviral activity against human cytomegalovirus (HCMV) at micromolar concentrations with promising selectivity. Exploitation of non‐covalent hydrogen‐bonding and electrostatic interactions has motivated the unprecedented discovery of these properties, opening new avenues of research for this iconic compound." @default.
- W4206103887 created "2022-01-26" @default.
- W4206103887 creator A5006751477 @default.
- W4206103887 creator A5028670417 @default.
- W4206103887 creator A5035776103 @default.
- W4206103887 creator A5055061785 @default.
- W4206103887 creator A5060238862 @default.
- W4206103887 creator A5060597313 @default.
- W4206103887 creator A5063863076 @default.
- W4206103887 creator A5071615572 @default.
- W4206103887 creator A5073392193 @default.
- W4206103887 creator A5079185884 @default.
- W4206103887 creator A5081885555 @default.
- W4206103887 creator A5089835420 @default.
- W4206103887 date "2021-06-27" @default.
- W4206103887 modified "2023-09-30" @default.
- W4206103887 title "On the Biology of Werner's Complex" @default.
- W4206103887 cites W1860795773 @default.
- W4206103887 cites W1991910899 @default.
- W4206103887 cites W1994980070 @default.
- W4206103887 cites W1999722506 @default.
- W4206103887 cites W2000976364 @default.
- W4206103887 cites W2010117209 @default.
- W4206103887 cites W2021751652 @default.
- W4206103887 cites W2022068706 @default.
- W4206103887 cites W2034589394 @default.
- W4206103887 cites W2035334692 @default.
- W4206103887 cites W2043889827 @default.
- W4206103887 cites W2047027724 @default.
- W4206103887 cites W2047044651 @default.
- W4206103887 cites W2068196033 @default.
- W4206103887 cites W2069514224 @default.
- W4206103887 cites W2070226860 @default.
- W4206103887 cites W2073898372 @default.
- W4206103887 cites W2077467056 @default.
- W4206103887 cites W2077886045 @default.
- W4206103887 cites W2078012443 @default.
- W4206103887 cites W2079954281 @default.
- W4206103887 cites W2083042395 @default.
- W4206103887 cites W2091329121 @default.
- W4206103887 cites W2093112418 @default.
- W4206103887 cites W2094270550 @default.
- W4206103887 cites W2096935674 @default.
- W4206103887 cites W2100402415 @default.
- W4206103887 cites W2105516832 @default.
- W4206103887 cites W2114404228 @default.
- W4206103887 cites W2123460424 @default.
- W4206103887 cites W2125504889 @default.
- W4206103887 cites W2132071999 @default.
- W4206103887 cites W2137179268 @default.
- W4206103887 cites W2140870123 @default.
- W4206103887 cites W2144144995 @default.
- W4206103887 cites W2146738165 @default.
- W4206103887 cites W2147027267 @default.
- W4206103887 cites W2230334371 @default.
- W4206103887 cites W2313563830 @default.
- W4206103887 cites W2346453055 @default.
- W4206103887 cites W2516401106 @default.
- W4206103887 cites W2560523744 @default.
- W4206103887 cites W2624979306 @default.
- W4206103887 cites W2772202981 @default.
- W4206103887 cites W2794168529 @default.
- W4206103887 cites W2798162624 @default.
- W4206103887 cites W2904777540 @default.
- W4206103887 cites W2942657569 @default.
- W4206103887 cites W2950147187 @default.
- W4206103887 cites W2989597965 @default.
- W4206103887 cites W3081697713 @default.
- W4206103887 cites W3093736043 @default.
- W4206103887 cites W3105334529 @default.
- W4206103887 cites W3139577909 @default.
- W4206103887 cites W4213237008 @default.
- W4206103887 cites W4233309778 @default.
- W4206103887 cites W4233635693 @default.
- W4206103887 cites W4246653996 @default.
- W4206103887 doi "https://doi.org/10.1002/ange.202105019" @default.
- W4206103887 hasPublicationYear "2021" @default.
- W4206103887 type Work @default.
- W4206103887 citedByCount "0" @default.
- W4206103887 crossrefType "journal-article" @default.
- W4206103887 hasAuthorship W4206103887A5006751477 @default.
- W4206103887 hasAuthorship W4206103887A5028670417 @default.
- W4206103887 hasAuthorship W4206103887A5035776103 @default.
- W4206103887 hasAuthorship W4206103887A5055061785 @default.
- W4206103887 hasAuthorship W4206103887A5060238862 @default.
- W4206103887 hasAuthorship W4206103887A5060597313 @default.
- W4206103887 hasAuthorship W4206103887A5063863076 @default.
- W4206103887 hasAuthorship W4206103887A5071615572 @default.
- W4206103887 hasAuthorship W4206103887A5073392193 @default.
- W4206103887 hasAuthorship W4206103887A5079185884 @default.
- W4206103887 hasAuthorship W4206103887A5081885555 @default.
- W4206103887 hasAuthorship W4206103887A5089835420 @default.
- W4206103887 hasConcept C153074725 @default.
- W4206103887 hasConcept C178790620 @default.
- W4206103887 hasConcept C180577832 @default.
- W4206103887 hasConcept C183882617 @default.
- W4206103887 hasConcept C185592680 @default.
- W4206103887 hasConcept C24107716 @default.