FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4206133045> ?p ?o ?g. }

• W4206133045 abstract "For seven decades, the pathophysiology of Good's syndrome (GS) has remained a mystery, with few attempts to solve it. Initially described as an association between hypogammaglobulinemia and thymoma, controversy exists whether this is a unique disease, or a subgroup of Common Variable Immune Deficiency (CVID). Recently, some distinguishing aspects of both syndromes have come to light reflecting fundamental differences in their underlying pathophysiology. GS and CVID differ in demographic features and immune phenotype. GS is found almost exclusively in adults and is characterized by a significantly reduced or absence of peripheral B cells. In CVID, which also occurs in children, most patients have normal or slightly reduced peripheral B cells, with a distinguishing feature of low memory B cells. Similarly, differences in T cell dysregulation and manifestations of hematologic cytopenias may further distinguish GS from CVID. Knowledge of the clinical phenotype of this rare adult immune deficiency stems from individual case reports, retrospective, and cross-sectional data on a few cohorts with a limited number of well characterized patients. The understanding of pathophysiology in GS is hampered by the incomplete and inconsistent reporting of clinical and laboratory data, with a limited knowledge of its natural history. In this mini review, we discuss current state of the art data and identify research gaps. In order to resolve controversies and fill in knowledge gaps, we propose a coordinated paradigm shift from incidence reporting to robust investigative studies, addressing mechanisms of disease. We hope this novel approach sets a clear direction to solve the current controversies." @default.
• W4206133045 created "2022-01-25" @default.
• W4206133045 creator A5014094352 @default.
• W4206133045 creator A5058280123 @default.
• W4206133045 creator A5058652695 @default.
• W4206133045 date "2022-01-12" @default.
• W4206133045 modified "2023-10-02" @default.
• W4206133045 title "Good’s Syndrome: Time to Move on From Reviewing the Past" @default.
• W4206133045 cites W110824614 @default.
• W4206133045 cites W135655435 @default.
• W4206133045 cites W1506804741 @default.
• W4206133045 cites W1553915350 @default.
• W4206133045 cites W1967829819 @default.
• W4206133045 cites W1969552308 @default.
• W4206133045 cites W1978141128 @default.
• W4206133045 cites W1995738251 @default.
• W4206133045 cites W1995839977 @default.
• W4206133045 cites W2009530651 @default.
• W4206133045 cites W2019355614 @default.
• W4206133045 cites W2023223254 @default.
• W4206133045 cites W2038004345 @default.
• W4206133045 cites W2038413203 @default.
• W4206133045 cites W2043651710 @default.
• W4206133045 cites W2055413966 @default.
• W4206133045 cites W2057266488 @default.
• W4206133045 cites W2060850391 @default.
• W4206133045 cites W2069431676 @default.
• W4206133045 cites W2080200324 @default.
• W4206133045 cites W2088144333 @default.
• W4206133045 cites W2114888352 @default.
• W4206133045 cites W2127403035 @default.
• W4206133045 cites W2134678353 @default.
• W4206133045 cites W2136699613 @default.
• W4206133045 cites W2142989775 @default.
• W4206133045 cites W2151988463 @default.
• W4206133045 cites W2168791265 @default.
• W4206133045 cites W2415065269 @default.
• W4206133045 cites W2496969299 @default.
• W4206133045 cites W2774787224 @default.
• W4206133045 cites W2892240084 @default.
• W4206133045 cites W2897811386 @default.
• W4206133045 cites W2898327170 @default.
• W4206133045 cites W2912052125 @default.
• W4206133045 cites W2967096583 @default.
• W4206133045 cites W2967488951 @default.
• W4206133045 cites W2986260829 @default.
• W4206133045 cites W2995688418 @default.
• W4206133045 cites W3044874692 @default.
• W4206133045 cites W3120023030 @default.
• W4206133045 cites W3120423766 @default.
• W4206133045 cites W3120805006 @default.
• W4206133045 cites W3136319625 @default.
• W4206133045 cites W3142481314 @default.
• W4206133045 cites W3165282247 @default.
• W4206133045 cites W4231363020 @default.
• W4206133045 doi "https://doi.org/10.3389/fimmu.2021.815710" @default.
• W4206133045 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35095915" @default.
• W4206133045 hasPublicationYear "2022" @default.
• W4206133045 type Work @default.
• W4206133045 citedByCount "7" @default.
• W4206133045 countsByYear W42061330452022 @default.
• W4206133045 countsByYear W42061330452023 @default.
• W4206133045 crossrefType "journal-article" @default.
• W4206133045 hasAuthorship W4206133045A5014094352 @default.
• W4206133045 hasAuthorship W4206133045A5058280123 @default.
• W4206133045 hasAuthorship W4206133045A5058652695 @default.
• W4206133045 hasBestOaLocation W42061330451 @default.
• W4206133045 hasConcept C10162356 @default.
• W4206133045 hasConcept C126322002 @default.
• W4206133045 hasConcept C159654299 @default.
• W4206133045 hasConcept C203014093 @default.
• W4206133045 hasConcept C2776433325 @default.
• W4206133045 hasConcept C2777805810 @default.
• W4206133045 hasConcept C2779134260 @default.
• W4206133045 hasConcept C2780194698 @default.
• W4206133045 hasConcept C71924100 @default.
• W4206133045 hasConcept C8891405 @default.
• W4206133045 hasConceptScore W4206133045C10162356 @default.
• W4206133045 hasConceptScore W4206133045C126322002 @default.
• W4206133045 hasConceptScore W4206133045C159654299 @default.
• W4206133045 hasConceptScore W4206133045C203014093 @default.
• W4206133045 hasConceptScore W4206133045C2776433325 @default.
• W4206133045 hasConceptScore W4206133045C2777805810 @default.
• W4206133045 hasConceptScore W4206133045C2779134260 @default.
• W4206133045 hasConceptScore W4206133045C2780194698 @default.
• W4206133045 hasConceptScore W4206133045C71924100 @default.
• W4206133045 hasConceptScore W4206133045C8891405 @default.
• W4206133045 hasFunder F4320329823 @default.
• W4206133045 hasLocation W42061330451 @default.
• W4206133045 hasLocation W42061330452 @default.
• W4206133045 hasLocation W42061330453 @default.
• W4206133045 hasLocation W42061330454 @default.
• W4206133045 hasOpenAccess W4206133045 @default.
• W4206133045 hasPrimaryLocation W42061330451 @default.
• W4206133045 hasRelatedWork W2043651710 @default.
• W4206133045 hasRelatedWork W2056840920 @default.
• W4206133045 hasRelatedWork W2085869929 @default.
• W4206133045 hasRelatedWork W2096513529 @default.
• W4206133045 hasRelatedWork W2144381846 @default.
• W4206133045 hasRelatedWork W2253670074 @default.

• next