FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4206133098> ?p ?o ?g. }

• W4206133098 abstract "Introduction: Ceramides, a family of bioactive sphingolipids on plasma membrane, have been implicated in inflammation, immune response, and HIV infection. Recent studies have related plasma ceramides with cardiovascular diseases (CVD), but data are sparse in HIV infected people who have excess CVD risk. Methods: We profiled baseline plasma ceramides C16:0, C22:0, C24:0 and C24:1 in 737 participants aged 35-55 years (520 HIV+, 217 HIV-) from two prospective cohorts (Women’s Interagency HIV Study and Multicenter AIDS Cohort Study) and examined their associations with the risk of incident carotid artery plaque (CAP), assessed by B-mode carotid artery ultrasound imaging over a 7-year period. Plasma levels of ceramides were inverse-normal transformed. We used robust variance estimates from Poisson regression to estimate risk ratios (RRs) on CAP per standard deviation increment in ceramides. We also compared ceramide levels by HIV infection status and antiretroviral therapy (ART) use. Results: Over a 7-year follow-up, 112 individuals developed CAP (90 HIV+, 22 HIV-). After multivariate adjustment, ceramides C16:0 (RR=1.40 [95% CI: 1.09-1.79]; P <0.001) and C24:1 (RR=1.32 [1.06-1.65]; P <0.001), but not ceramides C22:0 or C24:0, were significantly associated with increased risk of CAP in all participants. Ceramides C16:0 showed stronger association with CAP in HIV+ people compared to HIV- people ( Figure ), but there was no significant effect modification by HIV infection status ( P for interaction>0.05). Compared to HIV- group, plasma ceramides C16:0, C22:0 and C24:1 were significantly ( P <0.001) higher in HIV+ group. Further analyses in HIV+ group showed that ceramides were significantly ( P < 0.001) higher in people using ART than those not using ART. Conclusions: This study reported that elevated plasma ceramides, especially C16:0, are increased with ART use and associated with HIV-related atherosclerosis. Our data suggest that ceramides might be an intermediate link between HIV infection and CVD risk." @default.
• W4206133098 created "2022-01-25" @default.
• W4206133098 creator A5001266544 @default.
• W4206133098 creator A5005215114 @default.
• W4206133098 creator A5009987461 @default.
• W4206133098 creator A5014868299 @default.
• W4206133098 creator A5016102389 @default.
• W4206133098 creator A5037203447 @default.
• W4206133098 creator A5043696482 @default.
• W4206133098 creator A5047340885 @default.
• W4206133098 creator A5054590845 @default.
• W4206133098 creator A5058582987 @default.
• W4206133098 creator A5067731467 @default.
• W4206133098 creator A5068641801 @default.
• W4206133098 creator A5087768424 @default.
• W4206133098 date "2018-03-20" @default.
• W4206133098 modified "2023-09-28" @default.
• W4206133098 title "Abstract P186: Plasma Ceramides Are Associated With HIV Treatment and Increased Risk of Carotid Artery Plaque in Two Prospective HIV Cohorts" @default.
• W4206133098 doi "https://doi.org/10.1161/circ.137.suppl_1.p186" @default.
• W4206133098 hasPublicationYear "2018" @default.
• W4206133098 type Work @default.
• W4206133098 citedByCount "0" @default.
• W4206133098 crossrefType "journal-article" @default.
• W4206133098 hasAuthorship W4206133098A5001266544 @default.
• W4206133098 hasAuthorship W4206133098A5005215114 @default.
• W4206133098 hasAuthorship W4206133098A5009987461 @default.
• W4206133098 hasAuthorship W4206133098A5014868299 @default.
• W4206133098 hasAuthorship W4206133098A5016102389 @default.
• W4206133098 hasAuthorship W4206133098A5037203447 @default.
• W4206133098 hasAuthorship W4206133098A5043696482 @default.
• W4206133098 hasAuthorship W4206133098A5047340885 @default.
• W4206133098 hasAuthorship W4206133098A5054590845 @default.
• W4206133098 hasAuthorship W4206133098A5058582987 @default.
• W4206133098 hasAuthorship W4206133098A5067731467 @default.
• W4206133098 hasAuthorship W4206133098A5068641801 @default.
• W4206133098 hasAuthorship W4206133098A5087768424 @default.
• W4206133098 hasConcept C126322002 @default.
• W4206133098 hasConcept C185592680 @default.
• W4206133098 hasConcept C188816634 @default.
• W4206133098 hasConcept C190283241 @default.
• W4206133098 hasConcept C2777851122 @default.
• W4206133098 hasConcept C55493867 @default.
• W4206133098 hasConcept C71924100 @default.
• W4206133098 hasConcept C72563966 @default.
• W4206133098 hasConceptScore W4206133098C126322002 @default.
• W4206133098 hasConceptScore W4206133098C185592680 @default.
• W4206133098 hasConceptScore W4206133098C188816634 @default.
• W4206133098 hasConceptScore W4206133098C190283241 @default.
• W4206133098 hasConceptScore W4206133098C2777851122 @default.
• W4206133098 hasConceptScore W4206133098C55493867 @default.
• W4206133098 hasConceptScore W4206133098C71924100 @default.
• W4206133098 hasConceptScore W4206133098C72563966 @default.
• W4206133098 hasIssue "suppl_1" @default.
• W4206133098 hasLocation W42061330981 @default.
• W4206133098 hasOpenAccess W4206133098 @default.
• W4206133098 hasPrimaryLocation W42061330981 @default.
• W4206133098 hasRelatedWork W2025243002 @default.
• W4206133098 hasRelatedWork W2071535500 @default.
• W4206133098 hasRelatedWork W2092900223 @default.
• W4206133098 hasRelatedWork W2135329844 @default.
• W4206133098 hasRelatedWork W2295722933 @default.
• W4206133098 hasRelatedWork W2315085516 @default.
• W4206133098 hasRelatedWork W2316407790 @default.
• W4206133098 hasRelatedWork W2603773853 @default.
• W4206133098 hasRelatedWork W2952239533 @default.
• W4206133098 hasRelatedWork W2964295425 @default.
• W4206133098 hasVolume "137" @default.
• W4206133098 isParatext "false" @default.
• W4206133098 isRetracted "false" @default.
• W4206133098 workType "article" @default.