FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4206156187> ?p ?o ?g. }

• W4206156187 abstract "Although genetic factors play a main role in determining the risk of developing Alzheimer’s disease (AD), they do not explain extensive spectrum of clinicopathological phenotypes. Deposits of aggregated TAU proteins are one of the main predictors of cognitive decline in AD. We investigated the hypothesis that variabilities in AD progression could be due to diverse structural assemblies (strains) of TAU protein. Using sensitive biophysical methods in 40 patients with AD and markedly different disease durations, we identified populations of distinct TAU particles that differed in size, structural organization, and replication rate in vitro and in cell assay. The rapidly replicating, distinctly misfolded TAU conformers found in rapidly progressive AD were composed of ~80% misfolded four-repeat (4R) TAU and ~20% of misfolded 3R TAU isoform with the same conformational signatures. These biophysical observations suggest that distinctly misfolded population of 4R TAU conformers drive the rapid decline in AD and imply that effective therapeutic strategies might need to consider not a singular species but a cloud of differently misfolded TAU conformers." @default.
• W4206156187 created "2022-01-25" @default.
• W4206156187 creator A5009191561 @default.
• W4206156187 creator A5014473479 @default.
• W4206156187 creator A5017541508 @default.
• W4206156187 creator A5019424626 @default.
• W4206156187 creator A5021873304 @default.
• W4206156187 creator A5035346801 @default.
• W4206156187 creator A5046924858 @default.
• W4206156187 creator A5062244770 @default.
• W4206156187 creator A5062686238 @default.
• W4206156187 creator A5074064127 @default.
• W4206156187 creator A5076468468 @default.
• W4206156187 creator A5090052447 @default.
• W4206156187 date "2022-01-05" @default.
• W4206156187 modified "2023-10-18" @default.
• W4206156187 title "Distinct populations of highly potent TAU seed conformers in rapidly progressing Alzheimer’s disease" @default.
• W4206156187 cites W1493993470 @default.
• W4206156187 cites W1538218289 @default.
• W4206156187 cites W1541802751 @default.
• W4206156187 cites W1696941437 @default.
• W4206156187 cites W1765055414 @default.
• W4206156187 cites W1911074529 @default.
• W4206156187 cites W1917523610 @default.
• W4206156187 cites W1965078211 @default.
• W4206156187 cites W1965402821 @default.
• W4206156187 cites W1973894570 @default.
• W4206156187 cites W1977375958 @default.
• W4206156187 cites W1978959047 @default.
• W4206156187 cites W1980058823 @default.
• W4206156187 cites W1989150559 @default.
• W4206156187 cites W1996513738 @default.
• W4206156187 cites W1998744022 @default.
• W4206156187 cites W2000602998 @default.
• W4206156187 cites W2000639390 @default.
• W4206156187 cites W2001199794 @default.
• W4206156187 cites W2012541956 @default.
• W4206156187 cites W2014844151 @default.
• W4206156187 cites W2015329538 @default.
• W4206156187 cites W2019455663 @default.
• W4206156187 cites W2021031592 @default.
• W4206156187 cites W2023529808 @default.
• W4206156187 cites W2025658533 @default.
• W4206156187 cites W2026382038 @default.
• W4206156187 cites W2026426465 @default.
• W4206156187 cites W2028546773 @default.
• W4206156187 cites W2032169907 @default.
• W4206156187 cites W2035318781 @default.
• W4206156187 cites W2037372457 @default.
• W4206156187 cites W2040329943 @default.
• W4206156187 cites W2040504472 @default.
• W4206156187 cites W2046445620 @default.
• W4206156187 cites W2048881833 @default.
• W4206156187 cites W2049391304 @default.
• W4206156187 cites W2057293794 @default.
• W4206156187 cites W2059629233 @default.
• W4206156187 cites W2065995979 @default.
• W4206156187 cites W2067540111 @default.
• W4206156187 cites W2070878385 @default.
• W4206156187 cites W2072427499 @default.
• W4206156187 cites W2073038188 @default.
• W4206156187 cites W2076868663 @default.
• W4206156187 cites W2077790507 @default.
• W4206156187 cites W2077958711 @default.
• W4206156187 cites W2081966615 @default.
• W4206156187 cites W2084863049 @default.
• W4206156187 cites W2089569305 @default.
• W4206156187 cites W2093697965 @default.
• W4206156187 cites W2103913931 @default.
• W4206156187 cites W2104034347 @default.
• W4206156187 cites W2109938238 @default.
• W4206156187 cites W2110516310 @default.
• W4206156187 cites W2111828765 @default.
• W4206156187 cites W2113070267 @default.
• W4206156187 cites W2113259047 @default.
• W4206156187 cites W2115017507 @default.
• W4206156187 cites W2128030851 @default.
• W4206156187 cites W2128228199 @default.
• W4206156187 cites W2131001963 @default.
• W4206156187 cites W2132815274 @default.
• W4206156187 cites W2134462664 @default.
• W4206156187 cites W2138270253 @default.
• W4206156187 cites W2138390885 @default.
• W4206156187 cites W2143461767 @default.
• W4206156187 cites W2145356444 @default.
• W4206156187 cites W2146782587 @default.
• W4206156187 cites W2149529721 @default.
• W4206156187 cites W2152580129 @default.
• W4206156187 cites W2162741488 @default.
• W4206156187 cites W2165147575 @default.
• W4206156187 cites W2182763281 @default.
• W4206156187 cites W2192012340 @default.
• W4206156187 cites W2217289029 @default.
• W4206156187 cites W2259306322 @default.
• W4206156187 cites W2311580356 @default.
• W4206156187 cites W2330831003 @default.
• W4206156187 cites W2461531905 @default.
• W4206156187 cites W2558219596 @default.
• W4206156187 cites W2571390534 @default.
• W4206156187 cites W2593979775 @default.

• next