Matches in SemOpenAlex for { <https://semopenalex.org/work/W4206173610> ?p ?o ?g. }
- W4206173610 abstract "Alzheimer's disease (AD) is a form of neurodegenerative disease in the elderly with no cure at present. In a previous study, we found that the scaffold protein, disrupted in Schizophrenia 1 (DISC1) is down-regulated in the AD brains, and ectopic expression of DISC1 can delay the progression of AD by protecting synaptic plasticity and down-regulating BACE1. However, the underlying mechanisms remain not to be elucidated. In the present study, we compared the proteomes of normal and DISC1high AD cells expressing the amyloid precursor protein (APP) using isobaric tag for relative and absolute quantitation (iTRAQ) and mass spectrometry (MS). The differentially expressed proteins (DEPs) were identified, and the protein-protein interaction (PPI) network was constructed to identify the interacting partners of DISC1. Based on the interaction scores, NDE1, GRM3, PTGER3 and KATNA1 were identified as functionally or physically related to DISC1, and may therefore regulate AD development. The DEPs were functionally annotated by Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) databases with the DAVID software, and the Non-supervised Orthologous Groups (eggNOG) database was used to determine their evolutionary relationships. The DEPs were significantly enriched in microtubules and mitochondria-related pathways. Gene set enrichment analysis (GSEA) was performed to identify genes and pathways that are activated when DISC1 is overexpressed. Our findings provide novel insights into the regulatory mechanisms underlying DISC1 function in AD." @default.
- W4206173610 created "2022-01-25" @default.
- W4206173610 creator A5002315667 @default.
- W4206173610 creator A5007364999 @default.
- W4206173610 creator A5009888316 @default.
- W4206173610 creator A5021999315 @default.
- W4206173610 creator A5023963047 @default.
- W4206173610 creator A5034287211 @default.
- W4206173610 creator A5056014433 @default.
- W4206173610 creator A5057505964 @default.
- W4206173610 creator A5066904627 @default.
- W4206173610 creator A5078331136 @default.
- W4206173610 date "2022-01-01" @default.
- W4206173610 modified "2023-10-05" @default.
- W4206173610 title "Effects of DISC1 on Alzheimer’s disease cell models assessed by iTRAQ proteomics analysis" @default.
- W4206173610 cites W1581343682 @default.
- W4206173610 cites W1967016606 @default.
- W4206173610 cites W1991403431 @default.
- W4206173610 cites W1991744562 @default.
- W4206173610 cites W1993160420 @default.
- W4206173610 cites W2009165358 @default.
- W4206173610 cites W2035569961 @default.
- W4206173610 cites W2035618305 @default.
- W4206173610 cites W2037199116 @default.
- W4206173610 cites W2049438990 @default.
- W4206173610 cites W2059473497 @default.
- W4206173610 cites W2062858947 @default.
- W4206173610 cites W2072514788 @default.
- W4206173610 cites W2076948063 @default.
- W4206173610 cites W2085323811 @default.
- W4206173610 cites W2097088842 @default.
- W4206173610 cites W2097485803 @default.
- W4206173610 cites W2100159830 @default.
- W4206173610 cites W2103784702 @default.
- W4206173610 cites W2105043890 @default.
- W4206173610 cites W2119983609 @default.
- W4206173610 cites W2120307371 @default.
- W4206173610 cites W2121612337 @default.
- W4206173610 cites W2124135429 @default.
- W4206173610 cites W2130410032 @default.
- W4206173610 cites W2133465414 @default.
- W4206173610 cites W2134582937 @default.
- W4206173610 cites W2141282621 @default.
- W4206173610 cites W2158217645 @default.
- W4206173610 cites W2171776741 @default.
- W4206173610 cites W2223752691 @default.
- W4206173610 cites W2266996964 @default.
- W4206173610 cites W2354350348 @default.
- W4206173610 cites W2397701197 @default.
- W4206173610 cites W2470044260 @default.
- W4206173610 cites W2521991649 @default.
- W4206173610 cites W2530097218 @default.
- W4206173610 cites W2570615125 @default.
- W4206173610 cites W2573828241 @default.
- W4206173610 cites W2803664737 @default.
- W4206173610 cites W2900569176 @default.
- W4206173610 cites W2903015819 @default.
- W4206173610 cites W2985567251 @default.
- W4206173610 cites W3003627662 @default.
- W4206173610 cites W4210987525 @default.
- W4206173610 cites W4367165742 @default.
- W4206173610 cites W659052085 @default.
- W4206173610 doi "https://doi.org/10.1042/bsr20211150" @default.
- W4206173610 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34981809" @default.
- W4206173610 hasPublicationYear "2022" @default.
- W4206173610 type Work @default.
- W4206173610 citedByCount "4" @default.
- W4206173610 countsByYear W42061736102022 @default.
- W4206173610 countsByYear W42061736102023 @default.
- W4206173610 crossrefType "journal-article" @default.
- W4206173610 hasAuthorship W4206173610A5002315667 @default.
- W4206173610 hasAuthorship W4206173610A5007364999 @default.
- W4206173610 hasAuthorship W4206173610A5009888316 @default.
- W4206173610 hasAuthorship W4206173610A5021999315 @default.
- W4206173610 hasAuthorship W4206173610A5023963047 @default.
- W4206173610 hasAuthorship W4206173610A5034287211 @default.
- W4206173610 hasAuthorship W4206173610A5056014433 @default.
- W4206173610 hasAuthorship W4206173610A5057505964 @default.
- W4206173610 hasAuthorship W4206173610A5066904627 @default.
- W4206173610 hasAuthorship W4206173610A5078331136 @default.
- W4206173610 hasBestOaLocation W42061736101 @default.
- W4206173610 hasConcept C104317684 @default.
- W4206173610 hasConcept C104397665 @default.
- W4206173610 hasConcept C150194340 @default.
- W4206173610 hasConcept C152724338 @default.
- W4206173610 hasConcept C162317418 @default.
- W4206173610 hasConcept C2777568134 @default.
- W4206173610 hasConcept C46111723 @default.
- W4206173610 hasConcept C54355233 @default.
- W4206173610 hasConcept C70721500 @default.
- W4206173610 hasConcept C86803240 @default.
- W4206173610 hasConceptScore W4206173610C104317684 @default.
- W4206173610 hasConceptScore W4206173610C104397665 @default.
- W4206173610 hasConceptScore W4206173610C150194340 @default.
- W4206173610 hasConceptScore W4206173610C152724338 @default.
- W4206173610 hasConceptScore W4206173610C162317418 @default.
- W4206173610 hasConceptScore W4206173610C2777568134 @default.
- W4206173610 hasConceptScore W4206173610C46111723 @default.
- W4206173610 hasConceptScore W4206173610C54355233 @default.
- W4206173610 hasConceptScore W4206173610C70721500 @default.