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• W4206181885 abstract "A spiro ent-clerodane homodimer with a rare 6/6/6/6/6-fused pentacyclic scaffold, spiroarborin (1), together with four new monomeric analogues (2-5), were isolated from Callicarpa arborea. Their structures were elucidated by comprehensive spectroscopic data analysis, quantum-chemical calculations, and X-ray diffraction. A plausible biosynthetic pathway of 1 was proposed, and a biomimetic synthesis of its derivative was accomplished. Compound 1 showed a potent inhibitory effect by directly binding to the YEATS domain of the 11-19 leukemia (ENL) protein with an IC50 value of 7.3 μM. This gave a KD value of 5.0 μM, as recorded by a surface plasmon resonance binding assay." @default.
• W4206181885 created "2022-01-25" @default.
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• W4206181885 date "2022-01-14" @default.
• W4206181885 modified "2023-10-16" @default.
• W4206181885 title "Spiroarborin, an <i>ent</i>-Clerodane Homodimer from <i>Callicarpa arborea</i> as an Inhibitor of the Eleven-Nineteen Leukemia (ENL) Protein by Targeting the YEATS Domain" @default.
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• W4206181885 doi "https://doi.org/10.1021/acs.jnatprod.1c00775" @default.
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