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- W4206187410 abstract "Differentiated cells can be reprogrammed to an embryonic-like state by transfer of nuclear contents into oocytes or by fusion with embryonic stem (ES) cells. Little is known about factors that induce this reprogramming. Here, we demonstrate induction of pluripotent stem cells from mouse embryonic or adult fibroblasts by introducing four factors, Oct3/4, Sox2, c-Myc, and Klf4, under ES cell culture conditions. Unexpectedly, Nanog was dispensable. These cells, which we designated iPS (induced pluripotent stem) cells, exhibit the morphology and growth properties of ES cells and express ES cell marker genes. Subcutaneous transplantation of iPS cells into nude mice resulted in tumors containing a variety of tissues from all three germ layers. Following injection into blastocysts, iPS cells contributed to mouse embryonic development. These data demonstrate that pluripotent stem cells can be directly generated from fibroblast cultures by the addition of only a few defined factors. PMID: 16904174" @default.
- W4206187410 created "2022-01-25" @default.
- W4206187410 creator A5023056756 @default.
- W4206187410 date "2006-08-26" @default.
- W4206187410 modified "2023-09-27" @default.
- W4206187410 title "Faculty Opinions recommendation of Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors." @default.
- W4206187410 doi "https://doi.org/10.3410/f.30699.489069" @default.
- W4206187410 hasPublicationYear "2006" @default.
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