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- W4206242845 abstract "Abstract A Variant Surface Glycoprotein (VSG) coat protects bloodstream form Trypanosoma brucei . Prodigious amounts of VSG mRNA (~7-10% total) are generated from a single RNA polymerase I (Pol I) transcribed VSG expression site (ES), necessitating extremely high levels of localised splicing. We show that splicing is required for processive ES transcription, and describe novel ES-associated T. brucei nuclear bodies. In bloodstream form trypanosomes, the expression site body (ESB), spliced leader array body (SLAB), NUFIP body and Cajal bodies all frequently associate with the active ES. This assembly of nuclear bodies appears to facilitate the extraordinarily high levels of transcription and splicing at the active ES. In procyclic form trypanosomes, the NUFIP body and SLAB do not appear to interact with the Pol I transcribed procyclin locus. The congregation of a restricted number of nuclear bodies at a single active ES, provides an attractive mechanism for how monoallelic ES transcription is mediated." @default.
- W4206242845 created "2022-01-25" @default.
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- W4206242845 date "2022-01-10" @default.
- W4206242845 modified "2023-09-30" @default.
- W4206242845 title "An assembly of nuclear bodies associates with the active VSG expression site in African trypanosomes" @default.
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- W4206242845 doi "https://doi.org/10.1038/s41467-021-27625-6" @default.
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