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- W4206250897 abstract "Bone tumours comprise a heterogeneous mix of post-traumatic, developmental, benign, and malignant lesions. They can be subclassified according to their histological matrix as bone-forming, cartilage-forming, or fibre-forming, although some do not produce a specific matrix. Perhaps the most important distinction is between malignant tumours, which have a predisposition to invasive and destructive local growth and distant metastasis, and benign tumours, which do not metastasize, although some can demonstrate locally aggressive behaviour. Both benign and malignant bone tumours can present with unexplained pain and swelling. Radiographic investigation is mandatory to exclude bony malignancy, avoid delay in diagnosis, and prevent incorrect treatment such as arthroscopy or steroid injection when there is an underlying tumour. The three most common malignant tumours of bone are osteosarcoma, Ewing’s sarcoma, and chondrosarcoma. If radiography indicates that bone cancer is a possibility, an urgent referral should be made to a bone cancer multidisciplinary team. Wherever possible, patients should be entered into clinical trials. Some chemosensitive tumours (e.g. osteosarcoma or Ewing’s tumours) require a combined approach to treatment, classically with adjuvant (preoperative) chemotherapy, local therapy (usually surgery), then adjuvant chemotherapy." @default.
- W4206250897 created "2022-01-26" @default.
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- W4206250897 date "2013-10-01" @default.
- W4206250897 modified "2023-09-29" @default.
- W4206250897 title "Bone tumours" @default.
- W4206250897 doi "https://doi.org/10.1093/med/9780199642489.003.0147" @default.
- W4206250897 hasPublicationYear "2013" @default.
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