Matches in SemOpenAlex for { <https://semopenalex.org/work/W4206282081> ?p ?o ?g. }
Showing items 1 to 69 of
69
with 100 items per page.
- W4206282081 endingPage "616" @default.
- W4206282081 startingPage "605" @default.
- W4206282081 abstract "Ovarian cancer is the most common malignant disease leading to death among women. IL (interleukin)-17A is the most well-studied member of the IL-17 family, and has been demonstrated to play a critical role in host defenses against various microbial pathogens, as well as against tissue inflammation. T-helper (Th)17 cells that produce interleukin (IL)-17A are of particular importance, because IL-17A exerts a wide variety of biological functions, particularly related to inflammation and the resultant carcinogenesis, as well as immune suppression in patients with cancer, and IL-17A-targeted therapy has been proven to be effective in the treatment of some autoimmune diseases. The pathogenic features of Th17 and IL-17A cells in cancer are still controversial, and Th17 cells appear to promote disease progression, as well as be present in the vicinity of many types of malignant diseases. In cancer patients, MDSC (myeloid-derived suppressor cells), one of the major immunosuppressive immature cells, and VEGF (vascular endothelial growth factor) are reported to correlate each other and strongly connected to IL-17-driven inflammation and malnutrition. In the present review, the latest advances are presented about the basic features of IL-17A and Th17. The function of IL-17A has not been clarified especially in ovarian cancer. This review overview the basic features of IL-17A and the functions in ovarian cancer as well as in other malignant and non-malignant diseases. Increasing our understanding of the interactions between IL-17A and ovarian cancer could lead to new therapeutic strategies in oncology." @default.
- W4206282081 created "2022-01-26" @default.
- W4206282081 creator A5003235635 @default.
- W4206282081 creator A5004025326 @default.
- W4206282081 creator A5016853321 @default.
- W4206282081 creator A5019691878 @default.
- W4206282081 creator A5085436309 @default.
- W4206282081 creator A5088218136 @default.
- W4206282081 creator A5090779125 @default.
- W4206282081 date "2020-01-01" @default.
- W4206282081 modified "2023-09-28" @default.
- W4206282081 title "IL-17A in Ovarian Cancer" @default.
- W4206282081 doi "https://doi.org/10.4236/jct.2020.1110005" @default.
- W4206282081 hasPublicationYear "2020" @default.
- W4206282081 type Work @default.
- W4206282081 citedByCount "0" @default.
- W4206282081 crossrefType "journal-article" @default.
- W4206282081 hasAuthorship W4206282081A5003235635 @default.
- W4206282081 hasAuthorship W4206282081A5004025326 @default.
- W4206282081 hasAuthorship W4206282081A5016853321 @default.
- W4206282081 hasAuthorship W4206282081A5019691878 @default.
- W4206282081 hasAuthorship W4206282081A5085436309 @default.
- W4206282081 hasAuthorship W4206282081A5088218136 @default.
- W4206282081 hasAuthorship W4206282081A5090779125 @default.
- W4206282081 hasBestOaLocation W42062820811 @default.
- W4206282081 hasConcept C121608353 @default.
- W4206282081 hasConcept C126322002 @default.
- W4206282081 hasConcept C156730664 @default.
- W4206282081 hasConcept C203014093 @default.
- W4206282081 hasConcept C2776914184 @default.
- W4206282081 hasConcept C2779134260 @default.
- W4206282081 hasConcept C2780427987 @default.
- W4206282081 hasConcept C47348012 @default.
- W4206282081 hasConcept C502942594 @default.
- W4206282081 hasConcept C555283112 @default.
- W4206282081 hasConcept C71924100 @default.
- W4206282081 hasConcept C8891405 @default.
- W4206282081 hasConceptScore W4206282081C121608353 @default.
- W4206282081 hasConceptScore W4206282081C126322002 @default.
- W4206282081 hasConceptScore W4206282081C156730664 @default.
- W4206282081 hasConceptScore W4206282081C203014093 @default.
- W4206282081 hasConceptScore W4206282081C2776914184 @default.
- W4206282081 hasConceptScore W4206282081C2779134260 @default.
- W4206282081 hasConceptScore W4206282081C2780427987 @default.
- W4206282081 hasConceptScore W4206282081C47348012 @default.
- W4206282081 hasConceptScore W4206282081C502942594 @default.
- W4206282081 hasConceptScore W4206282081C555283112 @default.
- W4206282081 hasConceptScore W4206282081C71924100 @default.
- W4206282081 hasConceptScore W4206282081C8891405 @default.
- W4206282081 hasIssue "10" @default.
- W4206282081 hasLocation W42062820811 @default.
- W4206282081 hasOpenAccess W4206282081 @default.
- W4206282081 hasPrimaryLocation W42062820811 @default.
- W4206282081 hasRelatedWork W1557621914 @default.
- W4206282081 hasRelatedWork W172997010 @default.
- W4206282081 hasRelatedWork W1986406665 @default.
- W4206282081 hasRelatedWork W2014350403 @default.
- W4206282081 hasRelatedWork W2068614944 @default.
- W4206282081 hasRelatedWork W2133765154 @default.
- W4206282081 hasRelatedWork W2313033156 @default.
- W4206282081 hasRelatedWork W2900031363 @default.
- W4206282081 hasRelatedWork W2954839565 @default.
- W4206282081 hasRelatedWork W4206107686 @default.
- W4206282081 hasVolume "11" @default.
- W4206282081 isParatext "false" @default.
- W4206282081 isRetracted "false" @default.
- W4206282081 workType "article" @default.