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• W4206293852 startingPage "1104" @default.
• W4206293852 abstract "While type 2 immunity has traditionally been associated with the control of parasitic infections and allergic reactions, increasing evidence suggests that type 2 immunity exerts regulatory functions on inflammatory diseases such as arthritis, and also on bone homeostasis. This review summarizes the current evidence of the regulatory role of type 2 immunity in arthritis and bone. Key type 2 cytokines, like interleukin (IL)-4 and IL-13, but also others such as IL-5, IL-9, IL-25, and IL-33, exert regulatory properties on arthritis, dampening inflammation and inducing resolution of joint swelling. Furthermore, these cytokines share anti-osteoclastogenic properties and thereby reduce bone resorption and protect bone. Cellular effectors of this action are both T cells (i.e., Th2 and Th9 cells), but also non-T cells, like type 2 innate lymphoid cells (ILC2). Key regulatory actions mediated by type 2 cytokines and immune cells on both inflammation as well as bone homeostasis are discussed." @default.
• W4206293852 created "2022-01-26" @default.
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• W4206293852 creator A5055584432 @default.
• W4206293852 creator A5075261558 @default.
• W4206293852 date "2022-01-20" @default.
• W4206293852 modified "2023-10-01" @default.
• W4206293852 title "Inflammatory Arthritis and Bone Metabolism Regulated by Type 2 Innate and Adaptive Immunity" @default.
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