FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4206331503> ?p ?o ?g. }

• W4206331503 abstract "Background: Secukinumab has been shown effective for psoriatic arthritis (PsA) and axial spondylarthritis (AxSpA) in randomized trials. The aim of this study was to analyze baseline patient and disease characteristics associated with a better retention rate of secukinumab under real-world conditions. Patients and Methods: Real-life, prospective multicenter observational study involving 138 patients, 61 PsA and 77 AxSpA, who were analyzed at baseline, 6, 12 months and subsequently every year after starting secukinumab regardless of the line of treatment. Demographics and disease characteristics, measures of activity, secukinumab use, and adverse events were collected. Drug survival was analyzed using Kaplan-Meier curves and factors associated with discontinuation were evaluated using Cox regression. The machine-learning J48 decision tree classifier was also applied. Results: During the 1st year of treatment, 75% of patients persisted with secukinumab, but accrued 71% (n = 32) in total losses (n = 45). The backward stepwise (Wald) method selected diagnosis, obesity, and gender as relevant variables, the latter when analyzing the interactions. At 1 year of follow-up, the Cox model showed the best retention rate in the groups of AxSpa women (95%, 95% CI 93-97%) and PsA men (89%, 95% CI 84-93%), with the worst retention in PsA women (66%, 95% CI 54-79%). The J48 predicted secukinumab retention with an accuracy of 77.2%. No unexpected safety issues were observed. Conclusions: Secukinumab shows the best retention rate at 1 year of treatment in AxSpA women and in PsA men, independently of factors such as the time of disease evolution, the line of treatment or the initial dose of the drug." @default.
• W4206331503 created "2022-01-25" @default.
• W4206331503 creator A5018797113 @default.
• W4206331503 creator A5029767844 @default.
• W4206331503 creator A5034345091 @default.
• W4206331503 creator A5039722842 @default.
• W4206331503 creator A5051065833 @default.
• W4206331503 creator A5057872748 @default.
• W4206331503 creator A5065112437 @default.
• W4206331503 creator A5065672404 @default.
• W4206331503 date "2022-01-13" @default.
• W4206331503 modified "2023-10-18" @default.
• W4206331503 title "Association of Gender, Diagnosis, and Obesity With Retention Rate of Secukinumab in Spondyloarthropathies: Results Form a Multicenter Real-World Study" @default.
• W4206331503 cites W2013935756 @default.
• W4206331503 cites W2039448748 @default.
• W4206331503 cites W2079974518 @default.
• W4206331503 cites W2083180635 @default.
• W4206331503 cites W2103524303 @default.
• W4206331503 cites W2103874459 @default.
• W4206331503 cites W2116974527 @default.
• W4206331503 cites W2124045236 @default.
• W4206331503 cites W2128930739 @default.
• W4206331503 cites W2134083368 @default.
• W4206331503 cites W2156605473 @default.
• W4206331503 cites W2251592612 @default.
• W4206331503 cites W2278932593 @default.
• W4206331503 cites W2570670433 @default.
• W4206331503 cites W2606090416 @default.
• W4206331503 cites W2765937007 @default.
• W4206331503 cites W2789710874 @default.
• W4206331503 cites W2912967671 @default.
• W4206331503 cites W2947452967 @default.
• W4206331503 cites W2969598066 @default.
• W4206331503 cites W2972304813 @default.
• W4206331503 cites W2985533952 @default.
• W4206331503 cites W3010846977 @default.
• W4206331503 cites W3012396714 @default.
• W4206331503 cites W3013759133 @default.
• W4206331503 cites W3014764937 @default.
• W4206331503 cites W3022896986 @default.
• W4206331503 cites W3025736204 @default.
• W4206331503 cites W3036161997 @default.
• W4206331503 cites W3036984336 @default.
• W4206331503 cites W3047978234 @default.
• W4206331503 cites W3087606207 @default.
• W4206331503 cites W3117603710 @default.
• W4206331503 cites W3136535698 @default.
• W4206331503 cites W3159598855 @default.
• W4206331503 cites W3165270464 @default.
• W4206331503 cites W4211170289 @default.
• W4206331503 doi "https://doi.org/10.3389/fmed.2021.815881" @default.
• W4206331503 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35096907" @default.
• W4206331503 hasPublicationYear "2022" @default.
• W4206331503 type Work @default.
• W4206331503 citedByCount "4" @default.
• W4206331503 countsByYear W42063315032023 @default.
• W4206331503 crossrefType "journal-article" @default.
• W4206331503 hasAuthorship W4206331503A5018797113 @default.
• W4206331503 hasAuthorship W4206331503A5029767844 @default.
• W4206331503 hasAuthorship W4206331503A5034345091 @default.
• W4206331503 hasAuthorship W4206331503A5039722842 @default.
• W4206331503 hasAuthorship W4206331503A5051065833 @default.
• W4206331503 hasAuthorship W4206331503A5057872748 @default.
• W4206331503 hasAuthorship W4206331503A5065112437 @default.
• W4206331503 hasAuthorship W4206331503A5065672404 @default.
• W4206331503 hasBestOaLocation W42063315031 @default.
• W4206331503 hasConcept C126322002 @default.
• W4206331503 hasConcept C1862650 @default.
• W4206331503 hasConcept C2776260265 @default.
• W4206331503 hasConcept C2778715236 @default.
• W4206331503 hasConcept C2779134260 @default.
• W4206331503 hasConcept C2779786854 @default.
• W4206331503 hasConcept C50382708 @default.
• W4206331503 hasConcept C71924100 @default.
• W4206331503 hasConceptScore W4206331503C126322002 @default.
• W4206331503 hasConceptScore W4206331503C1862650 @default.
• W4206331503 hasConceptScore W4206331503C2776260265 @default.
• W4206331503 hasConceptScore W4206331503C2778715236 @default.
• W4206331503 hasConceptScore W4206331503C2779134260 @default.
• W4206331503 hasConceptScore W4206331503C2779786854 @default.
• W4206331503 hasConceptScore W4206331503C50382708 @default.
• W4206331503 hasConceptScore W4206331503C71924100 @default.
• W4206331503 hasLocation W42063315031 @default.
• W4206331503 hasLocation W42063315032 @default.
• W4206331503 hasLocation W42063315033 @default.
• W4206331503 hasLocation W42063315034 @default.
• W4206331503 hasOpenAccess W4206331503 @default.
• W4206331503 hasPrimaryLocation W42063315031 @default.
• W4206331503 hasRelatedWork W2946910872 @default.
• W4206331503 hasRelatedWork W3011669636 @default.
• W4206331503 hasRelatedWork W3034321784 @default.
• W4206331503 hasRelatedWork W3118690665 @default.
• W4206331503 hasRelatedWork W3165100449 @default.
• W4206331503 hasRelatedWork W3165270464 @default.
• W4206331503 hasRelatedWork W3201639315 @default.
• W4206331503 hasRelatedWork W4246832057 @default.
• W4206331503 hasRelatedWork W4293229883 @default.
• W4206331503 hasRelatedWork W4379647486 @default.
• W4206331503 hasVolume "8" @default.
• W4206331503 isParatext "false" @default.

• next