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- W4206335087 abstract "Translocation of the small GTP-binding protein Rac1 to the cell plasma membrane is essential for activating downstream effectors and requires integrin-mediated adhesion of cells to extracellular matrix. We report that active Rac1 binds preferentially to low-density, cholesterol-rich membranes, and specificity is determined at least in part by membrane lipids. Cell detachment triggered internalization of plasma membrane cholesterol and lipid raft markers. Preventing internalization maintained Rac1 membrane targeting and effector activation in nonadherent cells. Regulation of lipid rafts by integrin signals may regulate the location of membrane domains such as lipid rafts and thereby control domain-specific signaling events in anchorage-dependent cells. PMID: 14764880 Funding information This work was supported by: NIGMS NIH HHS, United States Grant ID: R01 GM47214 NHLBI NIH HHS, United States Grant ID: HL 20948 NIGMS NIH HHS, United States Grant ID: GM52016" @default.
- W4206335087 created "2022-01-26" @default.
- W4206335087 creator A5000246031 @default.
- W4206335087 date "2004-03-17" @default.
- W4206335087 modified "2023-09-28" @default.
- W4206335087 title "Faculty Opinions recommendation of Integrins regulate Rac targeting by internalization of membrane domains." @default.
- W4206335087 doi "https://doi.org/10.3410/f.1017246.206553" @default.
- W4206335087 hasPublicationYear "2004" @default.
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