Matches in SemOpenAlex for { <https://semopenalex.org/work/W4206344919> ?p ?o ?g. }
- W4206344919 abstract "Background: The hepatic lipidome of patients with early stages of non-alcoholic fatty liver disease (NAFLD) has been fairly well-explored. However, studies on more progressive forms of NAFLD, i.e., liver fibrosis, are limited. Materials and methods: Liver fatty acids were determined in cholesteryl esters (CE), phospholipids (PL), and triacylglycerols (TAG) by gas chromatography. Cross-sectional associations between fatty acids and biopsy-proven NAFLD fibrosis (n = 60) were assessed using multivariable logistic regression models. Stages of fibrosis were dichotomized into none-mild (F0-1) or significant fibrosis (F2-4). Models were adjusted for body-mass index (BMI), age and patatin-like phospholipase domain-containing protein 3 (PNPLA3 rs738409) (I148M) genotype. A secondary analysis examined whether associations from the primary analysis could be confirmed in the corresponding plasma lipid fractions. Results: PL behenic acid (22:0) was directly associated [OR (95% CI): 1.86 (1.00, 3.45)] whereas PL docosahexaenoic acid (22:6n-3) [OR (95% CI): 0.45 (0.23, 0.89)], TAG oleic acid (18:1n-9) [OR (95% CI): 0.52 (0.28, 0.95)] and 18:1n-9 and vaccenic acid (18:1n-7) (18:1) [OR (95% CI): 0.52 (0.28, 0.96)] were inversely associated with liver fibrosis. In plasma, TAG 18:1n-9 [OR (95% CI): 0.55 (0.31, 0.99)], TAG 18:1 [OR (95% CI): 0.54 (0.30, 0.97)] and PL 22:0 [OR (95% CI): 0.46 (0.25, 0.86)] were inversely associated with liver fibrosis. Conclusion: Higher TAG 18:1n-9 levels were linked to lower fibrosis in both liver and plasma, possibly reflecting an altered fatty acid metabolism. Whether PL 22:6n-3 has a protective role, together with a potentially adverse effect of hepatic 22:0, on liver fibrosis warrants large-scale studies." @default.
- W4206344919 created "2022-01-26" @default.
- W4206344919 creator A5001870958 @default.
- W4206344919 creator A5018404813 @default.
- W4206344919 creator A5021512169 @default.
- W4206344919 creator A5023269056 @default.
- W4206344919 creator A5026461159 @default.
- W4206344919 creator A5035717727 @default.
- W4206344919 creator A5036397323 @default.
- W4206344919 creator A5051111572 @default.
- W4206344919 creator A5052783896 @default.
- W4206344919 creator A5057422646 @default.
- W4206344919 creator A5068894725 @default.
- W4206344919 creator A5071795535 @default.
- W4206344919 date "2022-01-10" @default.
- W4206344919 modified "2023-10-05" @default.
- W4206344919 title "Hepatic Unsaturated Fatty Acids Are Linked to Lower Degree of Fibrosis in Non-alcoholic Fatty Liver Disease" @default.
- W4206344919 cites W1788320846 @default.
- W4206344919 cites W1964572117 @default.
- W4206344919 cites W1989260644 @default.
- W4206344919 cites W2000260253 @default.
- W4206344919 cites W2017975097 @default.
- W4206344919 cites W2060205727 @default.
- W4206344919 cites W2067191792 @default.
- W4206344919 cites W2072721395 @default.
- W4206344919 cites W2075341416 @default.
- W4206344919 cites W2093308509 @default.
- W4206344919 cites W2099110406 @default.
- W4206344919 cites W2120590794 @default.
- W4206344919 cites W2125507467 @default.
- W4206344919 cites W2147271582 @default.
- W4206344919 cites W2159223166 @default.
- W4206344919 cites W2171699937 @default.
- W4206344919 cites W2204688218 @default.
- W4206344919 cites W2331936027 @default.
- W4206344919 cites W2604660883 @default.
- W4206344919 cites W2609371482 @default.
- W4206344919 cites W2743667261 @default.
- W4206344919 cites W2794266645 @default.
- W4206344919 cites W2807637161 @default.
- W4206344919 cites W2809276781 @default.
- W4206344919 cites W2811307838 @default.
- W4206344919 cites W2910854646 @default.
- W4206344919 cites W2936962484 @default.
- W4206344919 cites W2954321663 @default.
- W4206344919 cites W2964856589 @default.
- W4206344919 cites W2997816433 @default.
- W4206344919 cites W3007812128 @default.
- W4206344919 cites W3017093333 @default.
- W4206344919 cites W3034949755 @default.
- W4206344919 cites W3097736804 @default.
- W4206344919 cites W3129891580 @default.
- W4206344919 cites W3153262091 @default.
- W4206344919 cites W3154897461 @default.
- W4206344919 doi "https://doi.org/10.3389/fmed.2021.814951" @default.
- W4206344919 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35083257" @default.
- W4206344919 hasPublicationYear "2022" @default.
- W4206344919 type Work @default.
- W4206344919 citedByCount "6" @default.
- W4206344919 countsByYear W42063449192022 @default.
- W4206344919 countsByYear W42063449192023 @default.
- W4206344919 crossrefType "journal-article" @default.
- W4206344919 hasAuthorship W4206344919A5001870958 @default.
- W4206344919 hasAuthorship W4206344919A5018404813 @default.
- W4206344919 hasAuthorship W4206344919A5021512169 @default.
- W4206344919 hasAuthorship W4206344919A5023269056 @default.
- W4206344919 hasAuthorship W4206344919A5026461159 @default.
- W4206344919 hasAuthorship W4206344919A5035717727 @default.
- W4206344919 hasAuthorship W4206344919A5036397323 @default.
- W4206344919 hasAuthorship W4206344919A5051111572 @default.
- W4206344919 hasAuthorship W4206344919A5052783896 @default.
- W4206344919 hasAuthorship W4206344919A5057422646 @default.
- W4206344919 hasAuthorship W4206344919A5068894725 @default.
- W4206344919 hasAuthorship W4206344919A5071795535 @default.
- W4206344919 hasBestOaLocation W42063449191 @default.
- W4206344919 hasConcept C126322002 @default.
- W4206344919 hasConcept C134018914 @default.
- W4206344919 hasConcept C142724271 @default.
- W4206344919 hasConcept C185592680 @default.
- W4206344919 hasConcept C19038510 @default.
- W4206344919 hasConcept C2775934546 @default.
- W4206344919 hasConcept C2777171753 @default.
- W4206344919 hasConcept C2777766500 @default.
- W4206344919 hasConcept C2778772119 @default.
- W4206344919 hasConcept C2779134260 @default.
- W4206344919 hasConcept C2779478299 @default.
- W4206344919 hasConcept C2780221984 @default.
- W4206344919 hasConcept C2780559512 @default.
- W4206344919 hasConcept C543025807 @default.
- W4206344919 hasConcept C55493867 @default.
- W4206344919 hasConcept C71924100 @default.
- W4206344919 hasConcept C90924648 @default.
- W4206344919 hasConceptScore W4206344919C126322002 @default.
- W4206344919 hasConceptScore W4206344919C134018914 @default.
- W4206344919 hasConceptScore W4206344919C142724271 @default.
- W4206344919 hasConceptScore W4206344919C185592680 @default.
- W4206344919 hasConceptScore W4206344919C19038510 @default.
- W4206344919 hasConceptScore W4206344919C2775934546 @default.
- W4206344919 hasConceptScore W4206344919C2777171753 @default.
- W4206344919 hasConceptScore W4206344919C2777766500 @default.