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- W4206357135 abstract "UNLABELLED: The term nanobacteria, sometimes referred to as nanobacteria-like particles (NLPs), is presently recognized as a misnomer for inert calcified nanoparticles. However, misinterpretation of its propagation as a living organism still continues. Ultrastructural and elemental analyses, combining immuno-electron microscopy with an original NLP isolate (P-17) derived from urinary stones, and an IgM monoclonal antibody (CL-15) raised against P-17 have now revealed that, oxidized lipids with acidified functional groups were key elements in NLP propagation. Lamellar structures composed of acidic/oxidized lipids provided structural scaffolds for carbonate apatite crystals. During in vitro culture, lipid peroxidation induced by γ-irradiation of FBS was a major cause of accelerated NLP propagation. In pathological tissue samples from hyperlipidemic atherosclerosis-prone mice, CL-15 co-localized with fatty plaques, macrophage infiltrates and osteocalcin staining of aortic valve lesions. These observations indicate that naturally occurring NLP composed of mineralo-oxidized lipids complexes are generated as by-products rather than etiological agents of chronic inflammation.FROM THE CLINICAL EDITOR: The term nanobacteria-like particles (NLPs) is presently recognized as a misnomer for inert calcified nanoparticles as opposed to living organisms. This study convincingly demonstrates that naturally occurring NLPs composed of mineralo-oxidized lipid complexes are generated as by-products rather than etiological agents of chronic inflammation.© 2014. PMID: 24028895" @default.
- W4206357135 created "2022-01-26" @default.
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- W4206357135 date "2013-10-18" @default.
- W4206357135 modified "2023-10-16" @default.
- W4206357135 title "Faculty Opinions recommendation of Ectopic calcification: importance of common nanoparticle scaffolds containing oxidized acidic lipids." @default.
- W4206357135 doi "https://doi.org/10.3410/f.718112313.793485438" @default.
- W4206357135 hasPublicationYear "2013" @default.
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