Matches in SemOpenAlex for { <https://semopenalex.org/work/W4206372010> ?p ?o ?g. }
- W4206372010 abstract "Immersive virtual reality (VR)-based motor control training (VRT) is an innovative approach to improve motor function in patients with stroke. Currently, outcome measures for immersive VRT mainly focus on motor function. However, serum biomarkers help detect precise and subtle physiological changes. Therefore, this study aimed to identify the effects of immersive VRT on inflammation, oxidative stress, neuroplasticity and upper limb motor function in stroke patients.Thirty patients with chronic stroke were randomized to the VRT or conventional occupational therapy (COT) groups. Serum biomarkers including interleukin 6 (IL-6), intracellular adhesion molecule 1 (ICAM-1), heme oxygenase 1 (HO-1), 8-hydroxy-2-deoxyguanosine (8-OHdG), and brain-derived neurotrophic factor (BDNF) were assessed to reflect inflammation, oxidative stress and neuroplasticity. Clinical assessments including active range of motion of the upper limb and the Fugl-Meyer Assessment for upper extremity (FMA-UE) were also used. Two-way mixed analyses of variance (ANOVAs) were used to examine the effects of the intervention (VRT and COT) and time on serum biomarkers and upper limb motor function.We found significant time effects in serum IL-6 (p = 0.010), HO-1 (p = 0.002), 8-OHdG (p = 0.045), and all items/subscales of the clinical assessments (ps < 0.05), except FMA-UE-Coordination/Speed (p = 0.055). However, significant group effects existed only in items of the AROM-Elbow Extension (p = 0.007) and AROM-Forearm Pronation (p = 0.048). Moreover, significant interactions between time and group existed in item/subscales of FMA-UE-Shoulder/Elbow/Forearm (p = 0.004), FMA-UE-Total score (p = 0.008), and AROM-Shoulder Flexion (p = 0.001).This was the first study to combine the effectiveness of immersive VRT using serum biomarkers as outcome measures. Our study demonstrated promising results that support the further application of commercial and immersive VR technologies in patients with chronic stroke." @default.
- W4206372010 created "2022-01-25" @default.
- W4206372010 creator A5014832869 @default.
- W4206372010 creator A5016761478 @default.
- W4206372010 creator A5030671253 @default.
- W4206372010 creator A5053644464 @default.
- W4206372010 creator A5062472621 @default.
- W4206372010 creator A5065757880 @default.
- W4206372010 creator A5090229064 @default.
- W4206372010 date "2022-01-11" @default.
- W4206372010 modified "2023-10-07" @default.
- W4206372010 title "Effects of virtual reality-based motor control training on inflammation, oxidative stress, neuroplasticity and upper limb motor function in patients with chronic stroke: a randomized controlled trial" @default.
- W4206372010 cites W1589715122 @default.
- W4206372010 cites W1853721709 @default.
- W4206372010 cites W1972214068 @default.
- W4206372010 cites W1974444241 @default.
- W4206372010 cites W1975868002 @default.
- W4206372010 cites W1994877858 @default.
- W4206372010 cites W2032612565 @default.
- W4206372010 cites W2040057126 @default.
- W4206372010 cites W2043983636 @default.
- W4206372010 cites W2064301927 @default.
- W4206372010 cites W2071765140 @default.
- W4206372010 cites W2075992165 @default.
- W4206372010 cites W2085895103 @default.
- W4206372010 cites W2087975086 @default.
- W4206372010 cites W2101398347 @default.
- W4206372010 cites W2114240561 @default.
- W4206372010 cites W2125006625 @default.
- W4206372010 cites W2125769302 @default.
- W4206372010 cites W2126511930 @default.
- W4206372010 cites W2136192280 @default.
- W4206372010 cites W2144398393 @default.
- W4206372010 cites W2154573186 @default.
- W4206372010 cites W2170853334 @default.
- W4206372010 cites W2172127559 @default.
- W4206372010 cites W2173374884 @default.
- W4206372010 cites W2216368555 @default.
- W4206372010 cites W2341104866 @default.
- W4206372010 cites W2436915575 @default.
- W4206372010 cites W2525535049 @default.
- W4206372010 cites W2525627827 @default.
- W4206372010 cites W2548852674 @default.
- W4206372010 cites W2550886340 @default.
- W4206372010 cites W2590308002 @default.
- W4206372010 cites W2622900209 @default.
- W4206372010 cites W2747892221 @default.
- W4206372010 cites W2886742436 @default.
- W4206372010 cites W2935825626 @default.
- W4206372010 cites W2982036210 @default.
- W4206372010 cites W2982539955 @default.
- W4206372010 cites W2990199154 @default.
- W4206372010 cites W3003271065 @default.
- W4206372010 cites W3003361666 @default.
- W4206372010 cites W3004639674 @default.
- W4206372010 cites W3006864780 @default.
- W4206372010 cites W3084305282 @default.
- W4206372010 cites W3117333497 @default.
- W4206372010 cites W3127753557 @default.
- W4206372010 cites W3156795291 @default.
- W4206372010 cites W3187076439 @default.
- W4206372010 doi "https://doi.org/10.1186/s12883-021-02547-4" @default.
- W4206372010 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35016629" @default.
- W4206372010 hasPublicationYear "2022" @default.
- W4206372010 type Work @default.
- W4206372010 citedByCount "9" @default.
- W4206372010 countsByYear W42063720102022 @default.
- W4206372010 countsByYear W42063720102023 @default.
- W4206372010 crossrefType "journal-article" @default.
- W4206372010 hasAuthorship W4206372010A5014832869 @default.
- W4206372010 hasAuthorship W4206372010A5016761478 @default.
- W4206372010 hasAuthorship W4206372010A5030671253 @default.
- W4206372010 hasAuthorship W4206372010A5053644464 @default.
- W4206372010 hasAuthorship W4206372010A5062472621 @default.
- W4206372010 hasAuthorship W4206372010A5065757880 @default.
- W4206372010 hasAuthorship W4206372010A5090229064 @default.
- W4206372010 hasBestOaLocation W42063720101 @default.
- W4206372010 hasConcept C102959455 @default.
- W4206372010 hasConcept C105795698 @default.
- W4206372010 hasConcept C118552586 @default.
- W4206372010 hasConcept C126322002 @default.
- W4206372010 hasConcept C127413603 @default.
- W4206372010 hasConcept C141071460 @default.
- W4206372010 hasConcept C16568411 @default.
- W4206372010 hasConcept C168563851 @default.
- W4206372010 hasConcept C1862650 @default.
- W4206372010 hasConcept C2776151105 @default.
- W4206372010 hasConcept C2776660947 @default.
- W4206372010 hasConcept C2776914184 @default.
- W4206372010 hasConcept C2780214079 @default.
- W4206372010 hasConcept C2780645631 @default.
- W4206372010 hasConcept C33923547 @default.
- W4206372010 hasConcept C47611674 @default.
- W4206372010 hasConcept C60465272 @default.
- W4206372010 hasConcept C71924100 @default.
- W4206372010 hasConcept C78519656 @default.
- W4206372010 hasConcept C99476002 @default.
- W4206372010 hasConcept C99508421 @default.
- W4206372010 hasConceptScore W4206372010C102959455 @default.
- W4206372010 hasConceptScore W4206372010C105795698 @default.