FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4206380558> ?p ?o ?g. }

• W4206380558 endingPage "226" @default.
• W4206380558 startingPage "226" @default.
• W4206380558 abstract "Hepatocellular carcinoma (HCC) constitutes a major health burden globally, and it is caused by intrinsic genetic mutations acting in concert with a multitude of epigenetic and extrinsic risk factors. Cancer induces myelopoiesis in the bone marrow, as well as the mobilization of hematopoietic stem and progenitor cells, which reside in the spleen. Monocytes produced in the bone marrow and the spleen further infiltrate tumors, where they differentiate into tumor-associated macrophages (TAMs). The relationship between chronic inflammation and hepatocarcinogenesis has been thoroughly investigated over the past decade; however, several aspects of the role of TAMs in HCC development are yet to be determined. In response to certain stimuli and signaling, monocytes differentiate into macrophages with antitumor properties, which are classified as M1-like. On the other hand, under different stimuli and signaling, the polarization of macrophages shifts towards an M2-like phenotype with a tumor promoting capacity. M2-like macrophages drive tumor growth both directly and indirectly, via the suppression of cytotoxic cell populations, including CD8+ T cells and NK cells. The tumor microenvironment affects the response to immunotherapies. Therefore, an enhanced understanding of its immunobiology is essential for the development of next-generation immunotherapies. The utilization of various monocyte-centered anticancer treatment modalities has been under clinical investigation, selectively targeting and modulating the processes of monocyte recruitment, activation and migration. This review summarizes the current evidence on the role of TAMs in HCC pathogenesis and progression, as well as in their potential involvement in tumor therapy, shedding light on emerging anticancer treatment methods targeting monocytes." @default.
• W4206380558 created "2022-01-26" @default.
• W4206380558 creator A5030925125 @default.
• W4206380558 creator A5064623738 @default.
• W4206380558 creator A5087679429 @default.
• W4206380558 creator A5088141005 @default.
• W4206380558 date "2022-01-04" @default.
• W4206380558 modified "2023-10-14" @default.
• W4206380558 title "Tumor-Associated Macrophages in Hepatocellular Carcinoma Pathogenesis, Prognosis and Therapy" @default.
• W4206380558 cites W1630847696 @default.
• W4206380558 cites W1882386136 @default.
• W4206380558 cites W1967912020 @default.
• W4206380558 cites W1971837077 @default.
• W4206380558 cites W1975949711 @default.
• W4206380558 cites W1977843046 @default.
• W4206380558 cites W1985544911 @default.
• W4206380558 cites W1988702078 @default.
• W4206380558 cites W1991691835 @default.
• W4206380558 cites W1996424780 @default.
• W4206380558 cites W2002858572 @default.
• W4206380558 cites W2006747130 @default.
• W4206380558 cites W2007122139 @default.
• W4206380558 cites W2008995080 @default.
• W4206380558 cites W2009670286 @default.
• W4206380558 cites W2012616131 @default.
• W4206380558 cites W2014663062 @default.
• W4206380558 cites W2023075736 @default.
• W4206380558 cites W2035013975 @default.
• W4206380558 cites W2035971119 @default.
• W4206380558 cites W2039892786 @default.
• W4206380558 cites W2042140414 @default.
• W4206380558 cites W2044383339 @default.
• W4206380558 cites W2060672294 @default.
• W4206380558 cites W2062390698 @default.
• W4206380558 cites W2065210647 @default.
• W4206380558 cites W2067606560 @default.
• W4206380558 cites W2070855360 @default.
• W4206380558 cites W2070968699 @default.
• W4206380558 cites W2075142845 @default.
• W4206380558 cites W2085252304 @default.
• W4206380558 cites W2088611209 @default.
• W4206380558 cites W2091528072 @default.
• W4206380558 cites W2091600198 @default.
• W4206380558 cites W2098236252 @default.
• W4206380558 cites W2100820895 @default.
• W4206380558 cites W2101327682 @default.
• W4206380558 cites W2101434865 @default.
• W4206380558 cites W2102310375 @default.
• W4206380558 cites W2106027870 @default.
• W4206380558 cites W2111691542 @default.
• W4206380558 cites W2115991409 @default.
• W4206380558 cites W2117362596 @default.
• W4206380558 cites W2117920462 @default.
• W4206380558 cites W2118998161 @default.
• W4206380558 cites W2122522101 @default.
• W4206380558 cites W2127438212 @default.
• W4206380558 cites W2132407294 @default.
• W4206380558 cites W2136166312 @default.
• W4206380558 cites W2150678612 @default.
• W4206380558 cites W2154239359 @default.
• W4206380558 cites W2154576630 @default.
• W4206380558 cites W2158809810 @default.
• W4206380558 cites W2162462666 @default.
• W4206380558 cites W2163478426 @default.
• W4206380558 cites W2166544072 @default.
• W4206380558 cites W2288773605 @default.
• W4206380558 cites W2304081485 @default.
• W4206380558 cites W2305530915 @default.
• W4206380558 cites W2325297427 @default.
• W4206380558 cites W2331667420 @default.
• W4206380558 cites W2343063221 @default.
• W4206380558 cites W2404869932 @default.
• W4206380558 cites W2414087903 @default.
• W4206380558 cites W2492767679 @default.
• W4206380558 cites W2512961065 @default.
• W4206380558 cites W2518270242 @default.
• W4206380558 cites W2520191991 @default.
• W4206380558 cites W2530995434 @default.
• W4206380558 cites W2537018529 @default.
• W4206380558 cites W2550399881 @default.
• W4206380558 cites W2560499218 @default.
• W4206380558 cites W2572415482 @default.
• W4206380558 cites W2580706718 @default.
• W4206380558 cites W2587532232 @default.
• W4206380558 cites W2587810271 @default.
• W4206380558 cites W2614947170 @default.
• W4206380558 cites W2616469279 @default.
• W4206380558 cites W2626033245 @default.
• W4206380558 cites W2730159658 @default.
• W4206380558 cites W2735915489 @default.
• W4206380558 cites W2755539654 @default.
• W4206380558 cites W2755601166 @default.
• W4206380558 cites W2761031851 @default.
• W4206380558 cites W2764159587 @default.
• W4206380558 cites W2769350174 @default.
• W4206380558 cites W2770003411 @default.
• W4206380558 cites W2773028871 @default.
• W4206380558 cites W2776333248 @default.

• next