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- W4206388105 abstract "Ribosomes are the molecular machine of living cells designed for decoding mRNA-encoded genetic information into protein. Being sophisticated machinery, both in design and function, the ribosome not only carries out protein synthesis, but also coordinates several other ribosome-associated cellular processes. One such process is the translocation of proteins across or into the membrane depending on their secretory or membrane-associated nature. These proteins comprise a large portion of a cell's proteome and act as key factors for cellular survival as well as several crucial functional pathways. Protein transport to extra- and intra-cytosolic compartments (across the eukaryotic endoplasmic reticulum (ER) or across the prokaryotic plasma membrane) or insertion into membranes majorly occurs through an evolutionarily conserved protein-conducting channel called translocon (eukaryotic Sec61 or prokaryotic SecYEG channels). Targeting proteins to the membrane-bound translocon may occur via post-translational or co-translational modes and it is often mediated by recognition of an N-terminal signal sequence in the newly synthesizes polypeptide chain. Co-translational translocation is coupled to protein synthesis where the ribosome-nascent chain complex (RNC) itself is targeted to the translocon. Here, in the light of recent advances in structural and functional studies, we discuss our current understanding of the mechanistic models of co-translational translocation, coordinated by the actively translating ribosomes, in prokaryotes and eukaryotes." @default.
- W4206388105 created "2022-01-26" @default.
- W4206388105 creator A5000542507 @default.
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- W4206388105 creator A5044920692 @default.
- W4206388105 creator A5082002902 @default.
- W4206388105 date "2022-01-01" @default.
- W4206388105 modified "2023-10-18" @default.
- W4206388105 title "Ribosome-membrane crosstalk: Co-translational targeting pathways of proteins across membranes in prokaryotes and eukaryotes" @default.
- W4206388105 cites W117684456 @default.
- W4206388105 cites W1507662338 @default.
- W4206388105 cites W1556324230 @default.
- W4206388105 cites W1563801633 @default.
- W4206388105 cites W1581080116 @default.
- W4206388105 cites W1608335176 @default.
- W4206388105 cites W1614372115 @default.
- W4206388105 cites W1818650289 @default.
- W4206388105 cites W1966357496 @default.
- W4206388105 cites W1968451768 @default.
- W4206388105 cites W1969633341 @default.
- W4206388105 cites W1973764696 @default.
- W4206388105 cites W1973925468 @default.
- W4206388105 cites W1974902012 @default.
- W4206388105 cites W1978110792 @default.
- W4206388105 cites W1979093610 @default.
- W4206388105 cites W1981610784 @default.
- W4206388105 cites W1984183888 @default.
- W4206388105 cites W1987515987 @default.
- W4206388105 cites W1987804131 @default.
- W4206388105 cites W1987882055 @default.
- W4206388105 cites W1990758117 @default.
- W4206388105 cites W2005518105 @default.
- W4206388105 cites W2006035995 @default.
- W4206388105 cites W2006132807 @default.
- W4206388105 cites W2007111091 @default.
- W4206388105 cites W2008223866 @default.
- W4206388105 cites W2009223706 @default.
- W4206388105 cites W2013582991 @default.
- W4206388105 cites W2015178379 @default.
- W4206388105 cites W2016718974 @default.
- W4206388105 cites W2019116905 @default.
- W4206388105 cites W2023127046 @default.
- W4206388105 cites W2023261130 @default.
- W4206388105 cites W2023481561 @default.
- W4206388105 cites W2023759124 @default.
- W4206388105 cites W2026676833 @default.
- W4206388105 cites W2028386037 @default.
- W4206388105 cites W2034791373 @default.
- W4206388105 cites W2036950925 @default.
- W4206388105 cites W2037708728 @default.
- W4206388105 cites W2038605297 @default.
- W4206388105 cites W2039877614 @default.
- W4206388105 cites W2050438256 @default.
- W4206388105 cites W2054022438 @default.
- W4206388105 cites W2054846678 @default.
- W4206388105 cites W2057013716 @default.
- W4206388105 cites W2060927340 @default.
- W4206388105 cites W2064254630 @default.
- W4206388105 cites W2067217155 @default.
- W4206388105 cites W2068874557 @default.
- W4206388105 cites W2072559002 @default.
- W4206388105 cites W2077345869 @default.
- W4206388105 cites W2079081359 @default.
- W4206388105 cites W2079772892 @default.
- W4206388105 cites W2081485603 @default.
- W4206388105 cites W2083157472 @default.
- W4206388105 cites W2086065113 @default.
- W4206388105 cites W2087069728 @default.
- W4206388105 cites W2087719108 @default.
- W4206388105 cites W2089039378 @default.
- W4206388105 cites W2090778722 @default.
- W4206388105 cites W2095509404 @default.
- W4206388105 cites W2099429838 @default.
- W4206388105 cites W2103778190 @default.
- W4206388105 cites W2104370757 @default.
- W4206388105 cites W2106445116 @default.
- W4206388105 cites W2109291482 @default.
- W4206388105 cites W2109613231 @default.
- W4206388105 cites W2119710091 @default.
- W4206388105 cites W2121484072 @default.
- W4206388105 cites W2122247301 @default.
- W4206388105 cites W2129954633 @default.
- W4206388105 cites W2131756959 @default.
- W4206388105 cites W2131865971 @default.
- W4206388105 cites W2131965246 @default.
- W4206388105 cites W2133105505 @default.
- W4206388105 cites W2138114721 @default.
- W4206388105 cites W2138438888 @default.
- W4206388105 cites W2138563074 @default.
- W4206388105 cites W2144287696 @default.
- W4206388105 cites W2146923243 @default.
- W4206388105 cites W2148171221 @default.
- W4206388105 cites W2148476409 @default.
- W4206388105 cites W2151234721 @default.
- W4206388105 cites W2151390847 @default.
- W4206388105 cites W2151832293 @default.
- W4206388105 cites W2153134143 @default.