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- W4206388601 abstract "The pharmacokinetics (PK) of a drug dictates its temporal profile within the body, including sites of activity and elimination, and hence the likely dose and regimen needed to attain and maintain a therapeutic response. Too rapid elimination often requires drug to be administered too frequently to be of practical value, too slow elimination may create problems when trying to remove the drug in cases of excessive toxicity, or will take too long to reach therapeutic levels on chronic administration. Poor absorption increases the oral dose needed to achieve adequate systemic exposure. Hence being able to predict the likely PK in humans prior to Phase 1 testing is desirable, thereby limiting the chances of taking poor candidates forward and so avoiding wasted resources and unnecessary animal safety assessment. Three approaches are employed to predict PK in human prior to Phase 1: allometry, physiologically based PK, and microdosing. The pros and cons of each method are presented and discussed. They are not mutually exclusive." @default.
- W4206388601 created "2022-01-25" @default.
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- W4206388601 date "2022-01-01" @default.
- W4206388601 modified "2023-09-25" @default.
- W4206388601 title "Preclinical prediction of human pharmacokinetics" @default.
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- W4206388601 doi "https://doi.org/10.1016/b978-0-12-819869-8.00007-0" @default.
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