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- W4206400577 abstract "<ns3:p><ns3:bold>Backgroundː</ns3:bold> Numerous <ns3:italic>in vivo</ns3:italic> human cohort studies have suggested that the apolipoprotein B100/apolipoprotein AI (ApoB100/ApoAI) ratio might be a risk factor in coronary heart disease. The aim of this study was to measure ApoB100/ApoAI ratio changes in cell secretions by incubating HepG2 cells with various amounts of glucose <ns3:italic>in vitro</ns3:italic>.</ns3:p><ns3:p> <ns3:bold>Methods</ns3:bold> <ns3:bold>ː </ns3:bold>HepG2 cells were cultured in low-, normal- or high-glucose Dulbecco's Modified Eagle Medium (DMEM) (1, 4.5 and 10g/L, respectively). Levels of ApoAI and ApoB100 were measured with commercial sandwich enzyme-linked immunosorbent assay kits (cat#: H0123 and H0124) from ShangHai MEIXUAN Biological Science and Technology Ltd (Shanghai, China). Experiments were repeated six times for each assay.</ns3:p><ns3:p> <ns3:bold>Resultsː</ns3:bold> The results showed that ApoB100/ApoAI ratio have positive correlations with the glucose concentration increase.</ns3:p><ns3:p> <ns3:bold>Conclusionsː</ns3:bold> A higher concentration of glucose induced an undesirable ApoB100/ApoAI ratio change, which suggests a new regulatory pathway in lipoprotein catabolism and provides a cell model for further mechanism study. This finding may lead to novel therapeutic ways for diagnosis and treatment for coronary artery disease.</ns3:p>" @default.
- W4206400577 created "2022-01-26" @default.
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- W4206400577 date "2022-01-10" @default.
- W4206400577 modified "2023-10-14" @default.
- W4206400577 title "Glucose induced ApoB100/ApoAI ratio changes in cultured HepG2 cells in vitro" @default.
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- W4206400577 doi "https://doi.org/10.12688/f1000research.55215.2" @default.
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