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• W4206438317 abstract "After human immunodeficiency virus type 1 (HIV-1) was identified in the early 1980s, intensive work began to understand the molecular basis of HIV-1 gene expression. Subgenomic HIV-1 RNA regions, spread throughout the viral genome, were described to have a negative impact on the nuclear export of some viral transcripts. Those studies revealed an intrinsic RNA code as a new form of nuclear export regulation. Since such regulatory regions were later also identified in other viruses, as well as in cellular genes, it can be assumed that, during evolution, viruses took advantage of them to achieve more sophisticated replication mechanisms. Here, we review HIV-1 cis-acting repressive sequences that have been identified, and we discuss their possible underlying mechanisms and importance. Additionally, we show how current bioinformatic tools might allow more predictive approaches to identify and investigate them." @default.
• W4206438317 created "2022-01-26" @default.
• W4206438317 creator A5030728705 @default.
• W4206438317 creator A5045171560 @default.
• W4206438317 creator A5052248312 @default.
• W4206438317 creator A5070260803 @default.
• W4206438317 date "2021-07-12" @default.
• W4206438317 modified "2023-10-14" @default.
• W4206438317 title "Let It Go: HIV-1 <i>cis</i> -Acting Repressive Sequences" @default.
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