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- W4206446840 abstract "Hypertension is a globally prevalent pathological condition and an underlying risk factor for the development of cardiac hypertrophy leading to heart failure. Myocyte enhancer factor 2 (Mef2) has been identified as one of the primary effectors of morphological changes in the hypertensive heart, as part of a complex network of molecular signaling controlling cardiac gene expression. Experimental chronic pressure-overload models that mimic hypertension in the mammalian heart lead to the activation of various pathological mechanisms that result in structural changes leading to debilitating cardiac hypertrophy and ultimately heart failure. The purpose here is to survey the literature implicating Mef2 in hypertension induced cardiac hypertrophy, towards illuminating points of interest for understanding and potentially treating heart failure." @default.
- W4206446840 created "2022-01-26" @default.
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- W4206446840 date "2023-05-01" @default.
- W4206446840 modified "2023-10-18" @default.
- W4206446840 title "MEF2 in cardiac hypertrophy in response to hypertension" @default.
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- W4206446840 doi "https://doi.org/10.1016/j.tcm.2022.01.002" @default.
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