Matches in SemOpenAlex for { <https://semopenalex.org/work/W4206466363> ?p ?o ?g. }
- W4206466363 endingPage "441" @default.
- W4206466363 startingPage "441" @default.
- W4206466363 abstract "Long-term cardiovascular complications of cancer therapy are becoming ever more prevalent due to increased numbers of cancer survivors. Cancer therapy-induced cardiotoxicity (CTIC) is an incompletely understood consequence of various chemotherapies, targeted anti-cancer agents and radiation therapy. It is typically detected clinically by a reduction in cardiac left ventricular ejection fraction, assessed by echocardiography. However, once cardiac functional decline is apparent, this indicates irreversible cardiac damage, highlighting a need for the development of diagnostics which can detect CTIC prior to the onset of functional decline. There is increasing evidence to suggest that pathological alterations to cardiac metabolism play a crucial role in the development of CTIC. This review discusses the metabolic alterations and mechanisms which occur in the development of CTIC, with a focus on doxorubicin, trastuzumab, imatinib, ponatinib, sunitinib and radiotherapy. Potential methods to diagnose and predict CTIC prior to functional cardiac decline in the clinic are evaluated, with a view to both biomarker and imaging-based approaches. Finally, the therapeutic potential of therapies which manipulate cardiac metabolism in the context of adjuvant cardioprotection against CTIC is examined. Together, an integrated view of the role of metabolism in pathogenesis, diagnosis and treatment is presented." @default.
- W4206466363 created "2022-01-25" @default.
- W4206466363 creator A5002750127 @default.
- W4206466363 creator A5024691158 @default.
- W4206466363 date "2021-12-31" @default.
- W4206466363 modified "2023-10-18" @default.
- W4206466363 title "Cancer Therapy-Induced Cardiotoxicity—A Metabolic Perspective on Pathogenesis, Diagnosis and Therapy" @default.
- W4206466363 cites W1492360552 @default.
- W4206466363 cites W1606511543 @default.
- W4206466363 cites W1818418090 @default.
- W4206466363 cites W1821222826 @default.
- W4206466363 cites W1828224642 @default.
- W4206466363 cites W1976655891 @default.
- W4206466363 cites W1977622321 @default.
- W4206466363 cites W1985703006 @default.
- W4206466363 cites W1990291053 @default.
- W4206466363 cites W1997849655 @default.
- W4206466363 cites W1998990808 @default.
- W4206466363 cites W2001122447 @default.
- W4206466363 cites W2015038969 @default.
- W4206466363 cites W2017193021 @default.
- W4206466363 cites W2018925169 @default.
- W4206466363 cites W2026640071 @default.
- W4206466363 cites W2033410404 @default.
- W4206466363 cites W2043759232 @default.
- W4206466363 cites W2043883927 @default.
- W4206466363 cites W2049093821 @default.
- W4206466363 cites W2050036109 @default.
- W4206466363 cites W2053590316 @default.
- W4206466363 cites W2059900570 @default.
- W4206466363 cites W2060404380 @default.
- W4206466363 cites W2060517558 @default.
- W4206466363 cites W2068449976 @default.
- W4206466363 cites W2071518542 @default.
- W4206466363 cites W2072140679 @default.
- W4206466363 cites W2073509884 @default.
- W4206466363 cites W2082181918 @default.
- W4206466363 cites W2085998534 @default.
- W4206466363 cites W2087476788 @default.
- W4206466363 cites W2090629996 @default.
- W4206466363 cites W2092896192 @default.
- W4206466363 cites W2099359513 @default.
- W4206466363 cites W2101425508 @default.
- W4206466363 cites W2102897174 @default.
- W4206466363 cites W2109775164 @default.
- W4206466363 cites W2111426313 @default.
- W4206466363 cites W2114825009 @default.
- W4206466363 cites W2119010176 @default.
- W4206466363 cites W2127284954 @default.
- W4206466363 cites W2128312247 @default.
- W4206466363 cites W2133359909 @default.
- W4206466363 cites W2147646179 @default.
- W4206466363 cites W2153087095 @default.
- W4206466363 cites W2154375587 @default.
- W4206466363 cites W2159594706 @default.
- W4206466363 cites W2162689981 @default.
- W4206466363 cites W2164427484 @default.
- W4206466363 cites W2167141775 @default.
- W4206466363 cites W2170401504 @default.
- W4206466363 cites W2183353693 @default.
- W4206466363 cites W2192294917 @default.
- W4206466363 cites W2221837786 @default.
- W4206466363 cites W2263791383 @default.
- W4206466363 cites W2412800896 @default.
- W4206466363 cites W2465092842 @default.
- W4206466363 cites W2512779800 @default.
- W4206466363 cites W2512832185 @default.
- W4206466363 cites W2520679741 @default.
- W4206466363 cites W2528999955 @default.
- W4206466363 cites W2531684896 @default.
- W4206466363 cites W2554612534 @default.
- W4206466363 cites W2555049274 @default.
- W4206466363 cites W2574924994 @default.
- W4206466363 cites W2579762198 @default.
- W4206466363 cites W2584674676 @default.
- W4206466363 cites W2596185607 @default.
- W4206466363 cites W2761912513 @default.
- W4206466363 cites W2766261199 @default.
- W4206466363 cites W2766794988 @default.
- W4206466363 cites W2791240087 @default.
- W4206466363 cites W2803030267 @default.
- W4206466363 cites W2886997484 @default.
- W4206466363 cites W2891824977 @default.
- W4206466363 cites W2897613436 @default.
- W4206466363 cites W2899024107 @default.
- W4206466363 cites W2908998660 @default.
- W4206466363 cites W2913126549 @default.
- W4206466363 cites W2913844318 @default.
- W4206466363 cites W2914897630 @default.
- W4206466363 cites W2919128688 @default.
- W4206466363 cites W2921772931 @default.
- W4206466363 cites W2921900038 @default.
- W4206466363 cites W2943822633 @default.
- W4206466363 cites W2953864461 @default.
- W4206466363 cites W2966319220 @default.
- W4206466363 cites W2967681759 @default.
- W4206466363 cites W2969928163 @default.
- W4206466363 cites W2974260792 @default.