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- W4206472824 endingPage "826" @default.
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- W4206472824 abstract "Recognition and capture of amyloid beta (Aβ) is a challenging task for the early diagnosis of neurodegenerative disorders, such as Alzheimer’s disease. Here, we report a novel KLVFF-modified nanomagnet based on magnetic nanoparticles (MNP) covered with a non-ionic amphiphilic β-cyclodextrin (SC16OH) and decorated with KLVFF oligopeptide for the self-recognition of the homologous amino-acids sequence of Aβ to collect Aβ (1–42) peptide from aqueous samples. [email protected] and [email protected]/Ada-Pep nanoassemblies were fully characterized by complementary techniques both as solid powders and in aqueous dispersions. Single domain [email protected]/Ada-Pep nanomagnets of 20–40 nm were observed by TEM analysis. DLS and ζ-potential measurements revealed that [email protected] nanoassemblies owned in aqueous dispersion a hydrodynamic radius of about 150 nm, which was unaffected by Ada-Pep decoration, while the negative ζ-potential of [email protected] (−40 mV) became less negative (−30 mV) in [email protected]/Ada-Pep, confirming the exposition of positively charged KLVFF on nanomagnets surface. The ability of [email protected]/Ada-Pep to recruit Aβ (1–42) in aqueous solution was evaluated by MALDI-TOF and compared with the ineffectiveness of undecorated [email protected] and VFLKF scrambled peptide-decorated nanoassemblies ([email protected]/Ada-scPep), pointing out the selectivity of KLVFF-decorated nanohybrid towards Aβ (1–42). Finally, the property of nanomagnets to extract Aβ in conditioned medium of cells over-producing Aβ peptides was investigated as proof of concept of effectiveness of these nanomaterials as potential diagnostic tools." @default.
- W4206472824 created "2022-01-26" @default.
- W4206472824 creator A5008843934 @default.
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- W4206472824 date "2022-05-01" @default.
- W4206472824 modified "2023-09-23" @default.
- W4206472824 title "KLVFF oligopeptide-decorated amphiphilic cyclodextrin nanomagnets for selective amyloid beta recognition and fishing" @default.
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- W4206472824 doi "https://doi.org/10.1016/j.jcis.2022.01.051" @default.