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• W4206501559 abstract "Only four cases of colorectal adenocarcinoma with a yolk sac tumor (YST) component have been reported in the English literature. No genetic investigation has been performed in these cases. We report a case of colorectal adenocarcinoma in which the recurrent tumor had a YST component. A 49-year-old woman presented with a pelvic tumor three years after endoscopic mucosal resection of sigmoid colon adenocarcinoma. The pelvic tumor consisted of an undifferentiated carcinoma component and a YST component. The serum alpha-fetoprotein level was elevated to 42 ng/mL. Treatment as conventional colorectal carcinoma produced some anticancer effects, but the patient died 14 months after the recurrence and 49 months after the EMR. With the help of the next-generation sequencing results of the recurrent tumor, APC c.835 − 8A > G and TP53 c.524G > A (p.R175H) mutations were identified by direct sequencing in both the primary and the recurrent tumors, confirming the relationship between the two metachronous tumors." @default.
• W4206501559 created "2022-01-25" @default.
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• W4206501559 date "2022-01-05" @default.
• W4206501559 modified "2023-09-27" @default.
• W4206501559 title "Yolk Sac Tumor in a Recurrence of Colonic Adenocarcinoma With Shared Mutations in<i>APC</i>and<i>TP53</i>Genes: A Case Report" @default.
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• W4206501559 doi "https://doi.org/10.1177/10668969211069963" @default.
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