Matches in SemOpenAlex for { <https://semopenalex.org/work/W4206513795> ?p ?o ?g. }
Showing items 1 to 48 of
48
with 100 items per page.
- W4206513795 endingPage "20" @default.
- W4206513795 startingPage "IA" @default.
- W4206513795 abstract "Abstract Genetic factors, together with other environmental and/or social factors, contribute to the risk of diseases in any population. There is a well-recognized need to be more inclusive of diverse populations in genetic studies, but several obstacles continue to exist, including, but not limited to, the difficulty of recruiting individuals from diverse populations in large numbers and the lack of representation in available genomic references. These obstacles notwithstanding, studying diverse populations would provide informative and population-specific insights important for the healthcare management of a population. As an example of an understudied population, the Native Hawaiians have a unique genetic history that can be leveraged to enhance the design and interpretation of genetic studies. It has been shown that the predominant Polynesian genetic ancestry component in Native Hawaiians is associated with elevated risk of cardiometabolic diseases. This finding is consistent with, though not a proof of, the hypothesis that there exist population-enriched genetic variants underlying the risk of these diseases. At the same time, currently available genomic resources underserve the Native Hawaiians due to a lack of representation, such that genetic variants strongly associated with diseases could not be systematically discovered. Therefore, by developing key genomic resources, integrating evolutionary thinking into genetic epidemiology, and partnering with the community, we will have the opportunity to efficiently advance our knowledge of the genetic risk factors, ameliorate health disparity, and improve healthcare in this underserved population. Citation Format: Charleston Chiang. The opportunities and challenges of integrating population histories into genetic studies for diverse populations [abstract]. In: Proceedings of the AACR Virtual Conference: 14th AACR Conference on the Science of Cancer Health Disparities in Racial/Ethnic Minorities and the Medically Underserved; 2021 Oct 6-8. Philadelphia (PA): AACR; Cancer Epidemiol Biomarkers Prev 2022;31(1 Suppl):Abstract nr IA-20." @default.
- W4206513795 created "2022-01-26" @default.
- W4206513795 creator A5020348074 @default.
- W4206513795 date "2022-01-01" @default.
- W4206513795 modified "2023-10-07" @default.
- W4206513795 title "Abstract IA-20: The opportunities and challenges of integrating population histories into genetic studies for diverse populations" @default.
- W4206513795 doi "https://doi.org/10.1158/1538-7755.disp21-ia-20" @default.
- W4206513795 hasPublicationYear "2022" @default.
- W4206513795 type Work @default.
- W4206513795 citedByCount "0" @default.
- W4206513795 crossrefType "journal-article" @default.
- W4206513795 hasAuthorship W4206513795A5020348074 @default.
- W4206513795 hasConcept C144024400 @default.
- W4206513795 hasConcept C149923435 @default.
- W4206513795 hasConcept C2522767166 @default.
- W4206513795 hasConcept C2908647359 @default.
- W4206513795 hasConcept C41008148 @default.
- W4206513795 hasConcept C54355233 @default.
- W4206513795 hasConcept C78458016 @default.
- W4206513795 hasConcept C86803240 @default.
- W4206513795 hasConceptScore W4206513795C144024400 @default.
- W4206513795 hasConceptScore W4206513795C149923435 @default.
- W4206513795 hasConceptScore W4206513795C2522767166 @default.
- W4206513795 hasConceptScore W4206513795C2908647359 @default.
- W4206513795 hasConceptScore W4206513795C41008148 @default.
- W4206513795 hasConceptScore W4206513795C54355233 @default.
- W4206513795 hasConceptScore W4206513795C78458016 @default.
- W4206513795 hasConceptScore W4206513795C86803240 @default.
- W4206513795 hasIssue "1_Supplement" @default.
- W4206513795 hasLocation W42065137951 @default.
- W4206513795 hasOpenAccess W4206513795 @default.
- W4206513795 hasPrimaryLocation W42065137951 @default.
- W4206513795 hasRelatedWork W1641042124 @default.
- W4206513795 hasRelatedWork W1990804418 @default.
- W4206513795 hasRelatedWork W1993764875 @default.
- W4206513795 hasRelatedWork W2013243191 @default.
- W4206513795 hasRelatedWork W2051339581 @default.
- W4206513795 hasRelatedWork W2061542922 @default.
- W4206513795 hasRelatedWork W2082860237 @default.
- W4206513795 hasRelatedWork W2117258802 @default.
- W4206513795 hasRelatedWork W2130076355 @default.
- W4206513795 hasRelatedWork W2151865869 @default.
- W4206513795 hasVolume "31" @default.
- W4206513795 isParatext "false" @default.
- W4206513795 isRetracted "false" @default.
- W4206513795 workType "article" @default.