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- W4206523623 abstract "Alzheimer's disease (AD) is a multifactorial neurodegenerative condition and the most common cause of its initiation is accumulation of oligomeric amyloid beta1-42 (Aβ1-42 ). In recent past, several studies have shown autophagy deficits in AD may resulted accumulation of misfolded protein, Aβ1-42 and phosphorylated tau (ptau). Fibroblast growth factor 21 (FGF21), a metabolic hormone, has shown strong neuroprotective efficacy via increasing autophagic flux in AD. Therefore, this study was designed to investigate the synergistic neuroprotective efficacy of lentiviral FGF21 gene (LV-FGF21) delivery and rapamycin-autophagy modulator in Aβ1-42 induced AD in rats.LV-FGF21 was administered 4weeks before inducing AD by oligomeric Aβ1-42 into the lateral cerebral ventricles. Rats were divided into control, sham group administered with PBS intracerebroventricularly (ICV), ICV-Aβ1-42 group, ICV-Aβ1-42 group pre-treated with LV-FGF21, and pre-treated LV-FGF21 group combined with rapamycin. Morris water maze (MWM), ELISA assay for measuring protein levels of Aβ1-42 , ptau, soluble amyloid precursor protein (sAPP) and beta-site APP cleaving enzyme 1 (BACE1), oxidative stress measurement, mRNA expression and immunofluorescence analysis were performed after treatment completion.Aβ1-42 oligomer formation was confirmed by FESEM analysis. After 14 days, MWM analysis showed that the combination group considerably restored the cognitive ability while attenuated the level of Aβ1-42 , ptau, sAPP, and BACE1. Moreover, oxidative stress parameters considerably improved for the combined treated group as compared with ICV-Aβ1-42 group. Also, mRNA expression of main autophagy mediators (beclin-1, LAMP-2, LC3, ATF4, p62/SQSTM1) reflected positive outcome for the combination treatment group.The findings of the present study confirmed the neuroprotective potential of FGF21 and rapamycin in debilitating AD pathology in rats." @default.
- W4206523623 created "2022-01-25" @default.
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- W4206523623 date "2021-12-01" @default.
- W4206523623 modified "2023-09-26" @default.
- W4206523623 title "Fibroblast Growth Factor 21 and Autophagy Modulation Ameliorates Amyloid β‐Induced Alzheimer Disease Pathology in Rats" @default.
- W4206523623 doi "https://doi.org/10.1002/alz.058695" @default.
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