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- W4206530667 abstract "A number of previously undescribed (1-7) and structurally related known (8-17) isobenzofuran-type polyketides were obtained from the fermentation of Penicillium commune P-4-1, an endophytic fungus isolated from the fresh trunk bark of the critically endangered conifer Abies beshanzuensis. Beshanzoides A-D (1-4, resp.) feature a cycloheptanone-containing isobenzofuran ring system hitherto unknown, which might be biosynthesized via two steps of aldol reactions starting from a common co-occurring isobenzofuran-type polyketide as the precursor. The new structures were elucidated by spectroscopic methods, electronic circular dichroism data, and single crystal X-ray diffraction analyses. Beshanzoide E (5) showed antimicrobial activity (MIC: 16 μg mL-1) against Staphylococcus aureus, whereas (±)-strobide A (10) inhibited (MIC: 16 μg mL-1) Candida albicans. Cyclopaldic acid (12) and 3-O-methyl-cyclopaldic acid (13) exhibited inhibitory effects against acetyl-CoA carboxylase 1 (ACC1) with IC50 values of 0.96 and 11.77 μM, respectively. Compound 12 also inhibited (IC50: 7.56 μM) ATP-citrate lyase (ACL)." @default.
- W4206530667 created "2022-01-26" @default.
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- W4206530667 date "2021-01-01" @default.
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- W4206530667 title "Beshanzoides A–D, unprecedented cycloheptanone-containing polyketides from <i>Penicillium commune</i> P-4-1, an endophytic fungus of the endangered conifer <i>Abies beshanzuensis</i>" @default.
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- W4206530667 doi "https://doi.org/10.1039/d1ra08377e" @default.
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