Matches in SemOpenAlex for { <https://semopenalex.org/work/W4206539897> ?p ?o ?g. }
- W4206539897 endingPage "110252" @default.
- W4206539897 startingPage "110252" @default.
- W4206539897 abstract "Ischemia-reperfusion (I/R) injury is the main reason why infarct size continues to progress during the process of restoring myocardial perfusion, and it significantly increases the risk of death. At present, the therapeutic effects of clinically used drugs are limited. Therefore, it is particularly necessary to explore myocardial-protective agents that effectively prevent I/R injury. Lycium barbarum polysaccharide (LBP) is a water-soluble polysaccharide extracted from wolfberry fruit. In this study, we found that LBP limited myocardial infarct size, improved adverse remodeling, and reduced cell death and oxidative stress. G protein-coupled receptor kinase-2 (GRK2) is a key molecule involved in myocardial I/R injury. In vivo and in vitro experiments showed that LBP inhibited the upregulation of GRK2 expression induced by I/R injury, which was related to the antiapoptotic effect of LBP. In addition, we found that LBP partially restored I/R-induced mitochondrial fission/fusion imbalance, as well as levels of phosphorylated protein kinase B (p-AKT) and phosphorylated endothelial cell nitric oxide synthase (p-eNOS), and this restorative effect could be attenuated by overexpression of GRK2. Overall, our findings suggest that LBP antagonizes cardiomyocyte apoptosis by inhibiting the upregulation of GRK2 induced by I/R injury and saves mitochondrial fission/fusion imbalance and AKT/eNOS signaling. This study may provide new ideas for the study of I/R injury and the rational application of the herbal medicine LBP." @default.
- W4206539897 created "2022-01-26" @default.
- W4206539897 creator A5007238584 @default.
- W4206539897 creator A5025477684 @default.
- W4206539897 creator A5032329002 @default.
- W4206539897 creator A5037201495 @default.
- W4206539897 creator A5054341281 @default.
- W4206539897 creator A5085793821 @default.
- W4206539897 date "2022-04-01" @default.
- W4206539897 modified "2023-10-15" @default.
- W4206539897 title "Lycium barbarum polysaccharide antagonizes cardiomyocyte apoptosis by inhibiting the upregulation of GRK2 induced by I/R injury, and salvage mitochondrial fission/fusion imbalance and AKT/eNOS signaling" @default.
- W4206539897 cites W1119734502 @default.
- W4206539897 cites W1607892649 @default.
- W4206539897 cites W1665122892 @default.
- W4206539897 cites W1698414284 @default.
- W4206539897 cites W1764272326 @default.
- W4206539897 cites W1964498676 @default.
- W4206539897 cites W1968155336 @default.
- W4206539897 cites W1970625672 @default.
- W4206539897 cites W1972382593 @default.
- W4206539897 cites W1979422883 @default.
- W4206539897 cites W2002170852 @default.
- W4206539897 cites W2004620514 @default.
- W4206539897 cites W2008721781 @default.
- W4206539897 cites W2009547397 @default.
- W4206539897 cites W2013399946 @default.
- W4206539897 cites W2015807984 @default.
- W4206539897 cites W2019637022 @default.
- W4206539897 cites W2030865896 @default.
- W4206539897 cites W2032773079 @default.
- W4206539897 cites W2043698693 @default.
- W4206539897 cites W2044929466 @default.
- W4206539897 cites W2047836890 @default.
- W4206539897 cites W2052302181 @default.
- W4206539897 cites W2052551280 @default.
- W4206539897 cites W2070545304 @default.
- W4206539897 cites W2085367705 @default.
- W4206539897 cites W2096751988 @default.
- W4206539897 cites W2117981319 @default.
- W4206539897 cites W2137086434 @default.
- W4206539897 cites W2137462234 @default.
- W4206539897 cites W2140474123 @default.
- W4206539897 cites W2145335113 @default.
- W4206539897 cites W2147561920 @default.
- W4206539897 cites W2147791296 @default.
- W4206539897 cites W2152916769 @default.
- W4206539897 cites W2157132367 @default.
- W4206539897 cites W2166137616 @default.
- W4206539897 cites W2167135536 @default.
- W4206539897 cites W2178720104 @default.
- W4206539897 cites W2187316482 @default.
- W4206539897 cites W2189560780 @default.
- W4206539897 cites W2308388038 @default.
- W4206539897 cites W2330210822 @default.
- W4206539897 cites W2508387453 @default.
- W4206539897 cites W2549344844 @default.
- W4206539897 cites W2594273820 @default.
- W4206539897 cites W2617012648 @default.
- W4206539897 cites W2623479910 @default.
- W4206539897 cites W2775714738 @default.
- W4206539897 cites W2885102453 @default.
- W4206539897 cites W2892460337 @default.
- W4206539897 cites W2898816123 @default.
- W4206539897 cites W2900734125 @default.
- W4206539897 cites W2900933295 @default.
- W4206539897 cites W2902122549 @default.
- W4206539897 cites W2925040060 @default.
- W4206539897 cites W2931214821 @default.
- W4206539897 cites W2964712707 @default.
- W4206539897 cites W2981535609 @default.
- W4206539897 cites W2987095718 @default.
- W4206539897 cites W3021421123 @default.
- W4206539897 cites W3088401235 @default.
- W4206539897 cites W3092359626 @default.
- W4206539897 cites W3114735434 @default.
- W4206539897 cites W3122226502 @default.
- W4206539897 cites W3136441200 @default.
- W4206539897 cites W3137629162 @default.
- W4206539897 cites W3160565526 @default.
- W4206539897 cites W3196750701 @default.
- W4206539897 cites W3197758711 @default.
- W4206539897 cites W3198017900 @default.
- W4206539897 cites W3198520091 @default.
- W4206539897 doi "https://doi.org/10.1016/j.cellsig.2022.110252" @default.
- W4206539897 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35065240" @default.
- W4206539897 hasPublicationYear "2022" @default.
- W4206539897 type Work @default.
- W4206539897 citedByCount "6" @default.
- W4206539897 countsByYear W42065398972022 @default.
- W4206539897 countsByYear W42065398972023 @default.
- W4206539897 crossrefType "journal-article" @default.
- W4206539897 hasAuthorship W4206539897A5007238584 @default.
- W4206539897 hasAuthorship W4206539897A5025477684 @default.
- W4206539897 hasAuthorship W4206539897A5032329002 @default.
- W4206539897 hasAuthorship W4206539897A5037201495 @default.
- W4206539897 hasAuthorship W4206539897A5054341281 @default.
- W4206539897 hasAuthorship W4206539897A5085793821 @default.
- W4206539897 hasConcept C104317684 @default.