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- W4206554951 abstract "A key quality attribute of any ADC is the mode of attachment of the linker-drug to the monoclonal antibody. Early generation technologies were based exclusively on one of two approaches, i.e. covalent bond formation with – abundantly available – lysine or cysteine sidechains. However, the need to develop ADCs with increased therapeutic index, and the insight that homogeneity, proper site selection, and stability all play a key role in this matter, has served as an inspiration for the development of a contemporary conjugation toolbox filled with alternative conjugation approaches. This chapter discusses in depth the state of the art in antibody conjugation, providing a comprehensive overview of technologies currently employed in clinical and late-stage preclinical ADC programs. The pros and cons of each technology are also discussed. Besides, a range of promising emerging technologies is highlighted, judged on their potential for application in next-generation ADCs." @default.
- W4206554951 created "2022-01-25" @default.
- W4206554951 creator A5050964428 @default.
- W4206554951 creator A5054629669 @default.
- W4206554951 date "2021-12-22" @default.
- W4206554951 modified "2023-09-24" @default.
- W4206554951 title "Antibody Conjugation Technologies" @default.
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- W4206554951 doi "https://doi.org/10.1039/9781839165153-00032" @default.
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