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- W4206567344 abstract "Asymmetric hydrogenation of tetrasubstituted alkenes remains a formidable challenge in asymmetric catalysis. We report herein an unprecedented Rh-catalyzed enantioselective and diastereoselective hydrogenation of easily accessed α,β-disubstituted unsaturated lactams to afford synthetically valuable chiral lactams with 1,2-consecutive stereocenters. The reaction could be performed on the gram scale, and the products could be concisely transformed to enantiomerically pure trans-3,4-disubstituted piperidines, which are prevalent structural units in medicinal agents." @default.
- W4206567344 created "2022-01-26" @default.
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- W4206567344 date "2022-01-10" @default.
- W4206567344 modified "2023-10-14" @default.
- W4206567344 title "Catalytic Asymmetric Hydrogenation of Tetrasubstituted Unsaturated Lactams: An Efficient Approach to Enantioenriched 3,4-Disubstituted Piperidines" @default.
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- W4206567344 doi "https://doi.org/10.1021/acs.orglett.1c04132" @default.
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