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- W4206590600 abstract "Abstract The combination of pharmacophoric nuclei with different targets has been a strategy for the development of new drugs aimed at improving cancer treatment. A series of ten novel phthalimido-thiazolidine-2-4-dione derivatives were synthesized by two different synthetic routes. The compounds were tested and evaluated in vitro , through antineoplastic activities against cancer cells. Cell cycle analyzes and clonogenic assay were also performed. In addition to these tests, in silico predictions were performed. The synthesized FT-12 compound (9j) exhibited antiproliferative activity against Panc-1, Sk-mel-28 and PC-3 cells. FT-12 reduced the ability to form new clones, also caused irreversibility in cell cycle, inducing arrest in phase S. Besides, the compound (FT-12) caused necrosis and apoptosis. The results suggest that phthalimido-thiazolidine derivatives may be useful in cancer therapy, highlighting compound FT-12 (9j) as a promising candidate. More studies must be carried out to confirm the viability." @default.
- W4206590600 created "2022-01-25" @default.
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- W4206590600 date "2021-07-28" @default.
- W4206590600 modified "2023-09-26" @default.
- W4206590600 title "Design, Synthesis and Biological Activities of New Phthalimide and Thiazolidine Derivatives" @default.
- W4206590600 doi "https://doi.org/10.21203/rs.3.rs-744351/v1" @default.
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